- Reactivity of potassium superoxide in heterogeneous phase: Oxidation of naphthalenediols and hydroxylated naphthoquinones
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Oxidation of dihydroxynaphthalenes by potassium superoxide (KO2) in heterogeneous aprotic media yields mono- or dihydroxynaphthoquinones, depending on the relative position of the hydroxy groups on the naphthalene moiety. The reaction proceeds mainly at the solid-liquid interface and naphthoquinones can be obtained with good yields.
- De Min,Croux,Tournaire,Hocquaux,Jacquet,Oliveros,Maurette
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p. 1869 - 1882
(2007/10/02)
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- Synthesis and pharmacology of some 2 aminotetralins. Dopamine receptor agonists
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A series of 2 amino 1,2,3,4 tetrahydronaphthalene compounds bearing substituents on the nitrogen and in the aromatic ring was synthesized from β tetralone intermediates. Compounds were screened in vivo for dopaminergic activity using tests in which apomorphine was especially active. It was found that apparent dopaminergic activity is inherent in 2 dialkylaminotetralins, the dipropylamine substitution being the most consistently productive amine group studied. Activity was greatly enhanced by proper substitution in the aromatic ring. The 5,6 dihydroxy group was the best potentiating group found. These data support the idea that the extended conformation for the phenylethylamine moiety of apomorphine and dopamine is favorable for dopaminergic agonist activity. They also suggest that an unetherified catechol group may not be essential for such activity.
- McDermed,McKenzie,Phillips
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p. 362 - 367
(2007/10/05)
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