- QSAR study on species differences in microsomal N-oxygenation of N,N-dimethylalkylamines
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The metabolic N-oxygenation of nine long chain N,N-dimethylalkylamines and tri-n-butylamine has been studied using hepatic microsomal homogenates from mice, dogs and guinea-pigs. The relative oxidizability of amines (ROA) was correlated with structure, lipophilicity and nucleophilicity parameters of substrates and corresponding amine oxides formed in this biological reaction. The highest conversions of amines to N-oxides was found with male guinea-pig, followed by dog (male, female) and the lowest amount of amine oxides has been produced with male mice microsomal homogenates. The analyses were carried out by GLC and the results quantified using QSAR methodology. ROA is parabolically dependent upon structure and physicochemical properties of the substrates and products which was proved by the high statistical significance of the regression equations. The biological N-oxygenation of these amines is controlled by lipophilicity, stereochemistry and electronic effects.
- Devinsky,Gorrod
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- AMINE OXIDES-XIII IODINE COMPLEXES WITH NON-AROMATIC AMINE OXIDES
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EDA-iodine complex with trialkylamine oxides in dichloromethane have been investigated spectrophotometrically.Thermodynamic (KADc,-ΔG0) and spectral (ΕADλ) characteristics of these complexes were determined.The absorption band of iodine in the visible region was blue-shifted with a variable maximum, depending on the structure of the amine oxide.The KADc and ΕADλ values were calculated using a modified method.A non-linear relationship KADc=(R), where R is the number of carbon atoms in the alkyl chain, was found.
- Devinsky, F.,Leitmanova, A.,Lacko, I.,Krasnec, L.
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p. 5707 - 5710
(2007/10/02)
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