Thienopyrimidine ureas as novel and potent multitargeted receptor tyrosine kinase inhibitors
A series of novel thienopyrimidine-based receptor tyrosine kinase inhibitors has been discovered. Investigation of structure-activity relationships at the 5- and 6-positions of the thienopyrimidine nucleus led to a series of N,N′-diaryl ureas that potentl
Dai, Yujia,Guo, Yan,Frey, Robin R.,Ji, Zhiqin,Curtin, Michael L.,Ahmed, Asma A.,Albert, Daniel H.,Arnold, Lee,Arries, Shannon S.,Barlozzari, Teresa,Bauch, Joy L.,Bouska, Jennifer J.,Bousquet, Peter F.,Cunha, George A.,Glaser, Keith B.,Guo, Jun,Li, Junling,Marcotte, Patrick A.,Marsh, Kennan C.,Moskey, Maria D.,Pease, Lori J.,Stewart, Kent D.,Stoll, Vincent S.,Tapang, Paul,Wishart, Neil,Davidsen, Steven K.,Michaelides, Michael R.
p. 6066 - 6083
(2007/10/03)
Thiopyrimidine and isothiazolopyrimidine kinase inhibitors
Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
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Page/Page column 35
(2008/06/13)
Thiopyrimidine and isothiazolopyrimidine kinase inhibitors
Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
-
Page 36
(2010/02/05)
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