- (AZA)INDOLE-, BENZOTHIOPHENE-, AND BENZOFURAN-3-SULFONAMIDES
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Disclosed are sulfonamide compounds with GPR17 modulating properties, which are useful for treating or preventing a variety of CNS and other diseases, in particular for preventing and treating myelinating diseases or disorders.
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- Gold nanoparticles-supported histamine-grafted monolithic capillaries as efficient microreactors for flow-through reduction of nitro-containing compounds
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A histamine functionalized monolith was synthesized within a micro-sized channel as a permeable support for the immobilization of 5, 20 and 100 nm-sized gold nanoparticles and the resulting nanostructured hybrid monoliths were applied as microreactors for the catalytic reduction of nitro-derivatives. The whole synthetic pathway of the composite materials relies on (i) UV-induced polymerization of N-acryloxysuccinimide and ethylene glycol dimethacrylate in toluene, (ii) surface grafting of histamine through nucleophilic substitution of hydroxysuccinimide leaving groups, and (iii) specific adsorption of citrate-stabilized colloidal gold nanoparticles. The achievement of the successive synthetic steps was ascertained by using a combination of experimental techniques providing information about the chemical composition (FTIR, Raman, and EDX) and porosity and surface-dispersion (SEM) of gold nanoparticles. Of particular interest, it is shown that surface-grafted histamine units exhibit strong affinity towards gold nanoparticles and allow homogeneous and dense dispersion of 5 and 20 nm sized nanoparticles. Consequently, the gold nanoparticle size-dependence of the catalytic activity (conversion of nitro and di-nitro aromatic compounds into the corresponding amino and di-amino-derivatives) was demonstrated, highlighting the utmost importance of controlling the dispersion of nano-catalysts on the support surface, while histamine protonation was also evidenced as a parameter of paramount importance regarding nanogold surface density and thus resulting catalytic activity. Histamine protonation notably allows the generation of electrostatic interactions between citrate-coated gold nanoparticles and thus-formed positive charges at the monolith surface.
- Liu,Guerrouache,Kebe,Carbonnier,Le Droumaguet
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p. 11805 - 11814
(2017/07/10)
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- Trinuclear {Co2+-M3+-Co2+} complexes catalyze reduction of nitro compounds
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This work presents synthesis and characterization of trinuclear {Co2+-Co3+-Co2+} and {Co2+-Fe3+-Co2+} complexes with accessible peripheral Co(ii) ions. Both trinuclear complexes function as efficient reusable heterogeneous catalysts for the selective reduction of assorted nitro compounds to the corresponding amines. The mechanistic investigations suggest the involvement of a Co(ii)-Co(i) cycle in the catalysis.
- Srivastava, Sumit,Dagur, Manvender S.,Ali, Afsar,Gupta, Rajeev
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p. 17453 - 17461
(2015/10/19)
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- Synthesis and characterization of Ni nanoparticles incorporated into hyperbranched polyamidoamine-polyvinylamine/SBA-15 catalyst for simple reduction of nitro aromatic compounds
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In this study, hyperbranched polyamidoamine (PAMAM) was grown up onto the surface of polyvinyl amine-functionalized SBA-15 (PVAm/SBA-15) by a divergent method, without using organosilane precursors. Because of the surface modification of the PVAm/SBA-15 w
- Kalbasi, Roozbeh Javad,Zamani, Farzad
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p. 7444 - 7453
(2014/02/14)
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- Fast and efficient reduction of nitro aromatic compounds over Fe 3O4/β-alanine-acrylamide-Ni nanocomposite as a new magnetic catalyst
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In this study, Ni nanoparticles incorporated β-alanine-acrylamide (Ala-AA) was successfully prepared by a simple method. The obtained magnetic nanocomposite exhibited excellent activity as a new heterogeneous magnetic catalyst for the reduction of a numbe
- Zamani, Farzad,Kianpour, Sahar
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- DISUBSTITUTED 3,4-DIAMINO-3-CYCLOBUTENE-1,2-DIONE COMPOUNDS FOR USE IN THE TREATMENT OF CHEMOKINE-MEDIATED PATHOLOGIES
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Disubstituted 3,4-diamino-3-cyclobutene-1,2-dione compounds are disclosed that are represented by general formula (I). Also disclosed, are pharmaceutical compositions including these compounds and methods of using these compounds and compositions for the
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Paragraph 0319; 0320
(2014/10/29)
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- Synthesis and characterization of Ni nanoparticles-polyvinylamine/SBA-15 catalyst for simple reduction of aromatic nitro compounds
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This work concerns the preparation and characterization of Nickel nanoparticle-PVAm/SBA-15, a polymer-inorganic hybrid composite, which was effectively employed as a novel heterogeneous catalyst for reduction of aromatic nitro compounds in the presence of
- Kalbasi, Roozbeh Javad,Nourbakhsh, Amir Abbas,Babaknezhad, Farzaneh
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experimental part
p. 955 - 960
(2012/01/06)
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- Regioselective syntheses of 1-,2-,3-and 4-aminoindolo-[2,3-b]quinoxalines
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In view of the contradictory results published in the literature concerning the structure of the indoloquinoxalines obtained by condensation of isatin with an unsymmetrical benzene-1,2-diamine, regioselective syntheses of the 1-, 2-, 3-, and 4-aminoindolo
- Jaouen, Aurelie,Helissey, Philippe,Desbene-Finck, Stephanie,Giorgi-Renault, Sylviane
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p. 2745 - 2759
(2011/04/17)
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- 1,1-DIOXO-1-THIA-5,10-DIAZADIBENZOCYCLOHEPTENES USEFUL AS HEPATITIS C VIRUS INHIBITORS
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Inhibitors of HCV replication of formula (I) the stereoisomers, prodrugs, tautomers, racemics, salts, hydrates or solvates thereof wherein R1a; R1b R2; R3; R4a and R4b have the meaning defi
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Page/Page column 131
(2008/12/08)
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- AMINOQUINOXALINE COMPOUND, POLYAMINOQUINOXALINE COMPOUND, AND USE THEREOF
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An aminoquinoxaline compound represented by the following formula (1a), and a polyaminoquinoxaline compound obtained by polymerizing the aminoquinoxaline compound, wherein R1 and R2 independently represent a hydrogen atom, a hydroxyl group, a C1-C10 alkyl group, a C1-C10 alkoxy group, or the like, R3 and R4 independently represent a hydrogen atom, a halogen atom, a cyano group, a nitro group, an amino group, a C1-C10 alkyl group, a C1-C10 alkoxy group or the like, and X1 represents -NH-R5-NH2 or -NH-R6.
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Page/Page column 27-28
(2008/06/13)
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- Reactivity of 4(7)-aminobenzimidazole as a bidentate nucleophile
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Reactivity of 4(7)-aminobenzimidazole as a bidentate nucleophile has been investigated. 7-H-Imidazo[1,5,4-e,f][1,5]benzodiazepin-4-ones or imidazo [4,5-h]quinoline derivatives are obtained with β-oxoesters or β-diketones respectively.
- Marcos,Pedregal,Avendano
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p. 7459 - 7464
(2007/10/02)
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- Preparation of esters of phosphorus acids
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Esters of phosphorus acids are prepared by an improved process whereby aromatic alcohols and phosphorus halides are reacted at specified temperatures in the presence of amine catalysts thereby providing high yields of substantially pure esters and allowing preparation of selected halogen-containing mono- and di-esters of phosphorus acids wherein halogen is directly bonded to phosphorus having substantially no side reactant contamination. The phosphorus esters are useful as intermediates in the preparation of plasticizers, oil additives and functional fluids.
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