- Synthesis and enantiomeric resolution of medetomidine
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Medetomidine {4-[l-(2,3-dimethylphenyl)ethyl]-3H-imidazole], 5} is a selective α2-adrenoceptor agonist used in veterinary medicine for its analgesic and sedative properties. It is also an alternative and environmentally acceptable anti-fouling biocide which impedes the settlement of barnacles at nanomolar concentrations and replaces toxic antifouling coatings based on heavy metals. Several syntheses of medetomidine have been reported. The first method for the preparation of 5 and of other related 4-benzylimidazoles was described in a patent starting from 2,3-dimethylbromobenzene as shown in Scheme 1; unfortunately the yields were not reported.
- Fakhraian,Toulabi,Choobdari,Peyrovi,Ghanbary, H. Hadj
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p. 141 - 148
(2015/05/20)
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- Transfer hydrogenation of aryl ketones with half-sandwich RuII complexes that contain chelating diamines
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In a comparative study, half-sandwich complexes of RuII (1) with pyridine-based chelating diamine [NN = 2-aminomethylpiperidine (ampi), a; 2-aminomethylpyridine (ampy), b; 8-aminoquaniline (aquan), c; 4,4'-dimethyl-2,2'-bipyridine (dbipy), d; 2,2'-bipyridine (bipy), e] or amine amide (Ts-ampi, 2a) were synthesized by cleavage of [{(η6-p- cymene)Ru(μ-Cl)Cl}2] dimer and the resulting complexes were screened for their efficiency in the transfer hydrogenation (TH) of acetophenone in 2-propanol (IPA) at 82 °C or in water in HCOONa. Among the complexes, cationic 1a, neutral 2a, and 1b, which bear ampi and ampy, were the most effective in terms of catalyst performance (turnover frequency values: 198, 6000, 23 h-1, respectively). Copyright
- Tuerkmen, Hayati,Cetinkaya, Bekir,Kani, Ibrahim
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p. 4494 - 4499,6
(2020/08/24)
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- PROCESS FOR THE PREPARATION OF MEDETOMIDINE
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A process of preparing Medetomidine of Formula (I) or an acid addition salt thereof, which process comprises: (i) reacting 2,3-dimethyl-methylbenzylalcohol with N-trimethylsilylimidazole, and, if desired, converting the Medetomidine to an acid addition salt thereof.
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Page/Page column 15-16
(2009/05/28)
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