ANTIBACTERIAL AND ANTIFUNGAL PLEUROMUTILIN CONJUGATES
Compounds of formula (1) comprising a pleuromutilin backbone with a triazole based side-group at C22 are provided. The compounds can be used for treatment of bacterial infections and fungal infections. Importantly, infections caused by multidrug-resistant
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Page/Page column 27-28
(2021/11/06)
A sulfonamide pleuromutilin derivative and its preparation method
The invention relates to pleuromutilin compounds and a preparation method thereof, particularly to sulfanilamide pleuromutilin derivatives and a preparation method thereof, which belongs to the field of chemically synthesized antibacterial drugs. Sulfanil
Synthesis of the pleuromutilin antibiotic SB-268091: A new practical and efficient synthesis of quinuclidine-4-thiol
A synthesis of the pleuromutilin antibiotic SB-268091 is described which includes a new and improved route to the quinuclidine-4-thiol ligand. This chemistry has been run on multikilo scale and involved a reductive double debenzylation using sodium in liquid ammonia. Alternative conditions have been developed to prepare quinuclidine-4-thiol which avoid the use of sodium in liquid ammonia. The generality of this process to prepare differentially S-protected quinuclidine-4-thiols is also discussed and exemplified by the preparation of a range of analogues.
Choudary, Bernie,Giles, Robert G.,Jovic, Florence,Lewis, Norman,Moore, Steve,Urquhart, Michael
p. 1927 - 1939
(2013/03/13)
PREPARATION OF RETAPAMULIN VIA ITS PLEUROMUTILIN-THIOL PRECURSOR
Provided are processes for preparation of Retapamulin via its pleuromutilin-thiol precursor
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Page/Page column 14
(2010/06/15)
Process for the preparation of Retapamulin and its intermediates
Processes for preparing tropine derivatives of the following Formula B are provided where LG represents a leaving group. The tropine derivatives may be used to prepare Retapamulin, preferably in substantially pure form. Also provided are processes for preparing Retapamulin comprising combining a base, tropine thiol in a free base or salt form, an organic solvent, and a pleuromutilin derivative of Formula A:
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Page/Page column 3; 4
(2009/06/27)
NOVEL POLYMORPH OF MUTILIN
Disclosed is a novel polymorphic form of the compound of formula (I) also known as mutilin 14-(exo-8-methyl-8-azabicyclo[3.2.1]oct-3-ylsulfanyl)-acetate, a process for the preparation of the polymorphic form, pharmaceutical compositions comprising the polymorphic form, and the use of the polymorphic form in medicine, particularly in antibacterial therapy.
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Page/Page column 7
(2008/06/13)
New pleuromutilin derivatives with enhanced antimicrobial activity. I. Synthesis
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Egger,Reinshagen
p. 915 - 922
(2007/10/05)
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