9-(4'-dimethylaminophenyl)-2,6,7-trihydroxy-xanthene-3-one is a potentially novel antiplatelet drug which antagonizes the effect of thromboxane A2
Background: Currently, used oral antiplatelet drugs are both limited and associated with the risk of treatment failure/resistance. Research in this area is hence highly desired. A series of xanthene-3-ones derivatives, we had synthesized, showed us that t
Applová, Lenka,Mlad?nka, P?emysl,Veljovi?, Elma,Muratovi?, Samija,Zavr?nik, Davorka,Karlí?ková, Jana,Macáková, Kate?ina,Saso, Luciano,Duri?, Kemal
p. 200 - 209
(2018/03/22)
Reliable synthesis of 9-aryl-substituted 2,6,7-trihydroxyxanthen-3-ones
2,6,7-Trihydroxyxanthen-3-ones are reliably prepared by a one-pot protocol using alkali peroxosulfates in the key step. NMR spectra in deuterated sodium hydroxide confirm the anticipated structures and allow the determination of the dye contents by an internal standard. Georg Thieme Verlag Stuttgart.
Schrick, Petra,Geick, Klaus,Waldvogel, Siegfried R.
experimental part
p. 2211 - 2216
(2009/04/06)
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