- Oxidative degradation of 2,4-dihydroxybenzoic acid by the Fenton and photo-Fenton processes: Kinetics, mechanisms, and evidence for the substitution of H2O2 by O2
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The kinetics and mechanisms of the oxidative degradation of 2,4-dihydroxybenzoic acid (2,4-DHBA) by the Fenton and photo-Fenton processes were investigated in detail by a combination of HPLC, IC, and TOC analyses. The formation of 2,3,4-trihydroxybenzoic
- Haddou, Menana,Benoit-Marquie, Florence,Maurette, Marie-Therese,Oliveros, Esther
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- Hydroxylation by Electrochemically Generated OH. Radicals. Mono- and Polyhydroxylation of Benzoic Acid: Products and Isomers' Distribution
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The electrochemical Fenton reaction (simultaneous reduction of dioxygen and ferric ions) permits a controlled production of OH. radicals.These are used for the stepwise hydroxylation of benzoic acid to mono- and polyhydroxylated products.The quantitative distribution of all the hydroxylated products is achieved by use of HPLC.The overall reaction scheme is established and the rate constants of the individual steps are measured.
- Oturan, Mehmet A.,Pinson, Jean
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p. 13948 - 13954
(2007/10/02)
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- Method for stimulating hair growth with cationic derivative of minoxidil using therapeutic iontophoresis
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This invention relates to a method of applying a cationic derivative of Minoxidil which is transported by means of iontophoresis to hair follicles where the cationic derivatives promote hair growth. Each of the cationic derivatives of Minoxidil are synthesized by reacting the Minoxidil parent compound with an organic or an inorganic acid to form the cationic derivative.
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- Synthesis of hydroxy- and amino-substituted benzohydroxamic acids: Inhibition of ribonucleotide reductase and antitumor activity
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Benzohydroxamic acids inhibit mammalian ribonucleotide reductase and exhibit antineoplastic activity in L1210 leukemic mice. Five new hydroxy- and amino-substituted benzohydroxamic acids (3,4- and 3,5-OH,3,4-NH2, 2,3,4-, and 3,4,5-OH) were prepared and tested along with 12 previously reported benzohydroxamic acids (BHA) for enzyme inhibition and antitumor activity. The most potent enzyme inhibitor in this series was 2,3,4-OH-BHA (ID50=3.5 μM), which is 140 times more potent than hydroxyurea, but its toxicity limited the antitumor activity to a 30% increase in life span of L1210 bearing mice at 125 (mg/kg) day ip for 8 days. The most effective antitumor agent in this series was 3,4-OH-BHA which prolonged the life span of L1210 bearing mice 103% at 600 (mg/kg)/day ip for 8 days.
- van't Riet,Wampler,Elford
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p. 589 - 592
(2007/10/05)
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