Interaction between Oxytetracycline Sulphosalicylate and Calcium Chloride
Oxytetracycline sulphosalicylate (OTc-SAA) and calcium chloride react in methanol to furnish a product characterised as oxytetracycline hydrochloride (OTc.HCl) by spectrophotometric technique and other supporting evidences.This constitutes a novel method in the field of tetracyclines wherein isolation of substantially pure OTc.HCl in ca. 80percent yield is achieved without employing hydrochloric acid.
Issar, M. M.,Mahadevan, P. R.
p. 257 - 258
(2007/10/02)
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