CONTINUOUS PRODUCTION AND REACTION OF A DIAZO COMPOUND
A process for producing a reaction product of a diazo compound, which process comprises: a. continuously supplying to a first reactor a precursor of a diazo compound; a water-miscible solvent; a base and water; b. mixing the precursor of a diazo compound; the water-miscible solvent; the base and water to generate a diazo compound; c. continuously removing from the first reactor, through a hydrophobic membrane, into a second reactor the formed diazo compound; d. continuously removing from the first reactor all reaction products that have not passed into the second reactor; e. continuously supplying to the second reactor a substrate in a non-water-miscible solvent; f. mixing the above components to generate a reaction product of a diazo compound; and g. continuously removing from the second reactor the non-water-miscible solvent and the reaction product of the diazo compound, and apparatus suitable for carrying out such a process.
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Page/Page column 15-16
(2012/05/20)
Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP
Inspired by previous efforts in the pyrazolobenzoxazine class of KSP inhibitors, the design and synthesis of 1,4-diaryl-4,5-dihydropyrazole inhibitors of KSP are described. Crystallographic evidence of binding mode and in vivo potency data is also highlig
Roecker, Anthony J.,Coleman, Paul J.,Mercer, Swati P.,Schreier, John D.,Buser, Carolyn A.,Walsh, Eileen S.,Hamilton, Kelly,Lobell, Robert B.,Tao, Weikang,Diehl, Ronald E.,South, Vicki J.,Davide, Joseph P.,Kohl, Nancy E.,Yan, Youwei,Kuo, Lawrence C.,Li, Chunze,Fernandez-Metzler, Carmen,Mahan, Elizabeth A.,Prueksaritanont, Thomayant,Hartman, George D.
p. 5677 - 5682
(2008/03/14)
MITOTIC KINESIN INHIBITORS
The present invention relates to dihydropyrazole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to composition
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Page/Page column 46-47
(2008/06/13)
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