- Nickel-Catalyzed reductive cross-Coupling of unactivated alkyl halides
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A Ni-catalyzed reductive approach to the cross-coupling of two unactivated alkyl halides has been successfully developed. The reaction works efficiently for primary and secondary halides, with at least one being bromide. The mild reaction conditions allow for excellent functional group tolerance and provide the C(sp3)-C(sp3) coupling products in moderate to excellent yields.
- Yu, Xiaolong,Yang, Tao,Wang, Shulin,Xu, Hailiang,Gong, Hegui
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supporting information; experimental part
p. 2138 - 2141
(2011/06/22)
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- COMPOUNDS FOR INHIBITING KSP KINESIN ACTIVITY
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The present invention provides compounds of Formula (I) (wherein R1, R3, X, W, Z and ring Y are as defined herein). The present invention also provides compositions comprising these compounds that are useful for treating cellular proliferative diseases or disorders associated with KSP kinesin activity and for inhibiting KSP kinesin activity.
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Page/Page column 99
(2010/11/23)
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- Assessing the Substrate Selectivities and Enantioselectivities of Eight Novel Baeyer-Villiger Monooxygenases toward Alkyl-Substituted Cyclohexanones
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Genes encoding eight Baeyer-Villiger monooxygenases have recently been cloned from bacteria inhabiting a wastewater treatment plant. We have carried out a systematic investigation in which each newly cloned enzyme, as well as the cyclohexanone monooxygenase from Acinetobacter sp. NCIB 9871, was used to oxidize 15 different alkyl-substituted cyclohexanones. The panel of substrates included equal numbers of 2-, 3-, and 4-alkyl-substituted compounds to probe each enzyme's stereoselectivity toward a homologous series of synthetically important compounds. For all 4-alkyl-substituted cyclohexanones tested, enzymes were discovered that afforded each of the corresponding (S)-lactones in ≥98% ee. This was also true for the 2-alkyl-substituted cyclohexanones examined. The situation was more complex for 3-akyl-substituted cyclohexanones. In a few cases, single Baeyer-Villiger monooxygenases possessed both high regio- and enantioselectivities toward these compounds. More commonly, however, they showed only one type of selectivity. Nonetheless, enzymes with such properties might be useful as parts of a two-step bioprocess where an initial kinetic resolution is followed by a regioselective oxidation on the isolated, optically pure ketone.
- Kyte, Brian G.,Rouviere, Pierre,Cheng, Qiong,Stewart, Jon D.
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- Gas Chromatography/Electron Impact Mass Spectrometry Applied to the Differentiation of the Positional Isomers of Long-chain n-Alkylcyclohexanones
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The influence of n-butyl group position upon the fragmentation behaviour of the three isomeric n-butylcyclohexanones was studied.The different fragmentation processes are described and have been applied to the differentation of the positional isomers of long-chain n-alkylcyclohexanones.In the case of the 4-n-alkyl isomers, an interesting mechanism involving a recyclization is proposed and substantiated by deuterium labelling.
- Rontani, J.-F.,Giusti, G.
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p. 773 - 776
(2007/10/02)
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- A STABLE 1:1 LITHIUM ACYLCYANOCUPRATE. DEPENDENCE OF THE STABILITY OF ACYLCYANOCUPRATES ON THE NATURE OF THE ALKYL SUBSTITUENT.
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Acylcuprates obtained by carbonylation of R(CN)CuLi cuprates (R=t-Bu, sec-Bu) at low temperature are effective in the direct nucleophilic 1,4-acylation of α,β-unsaturated ketones and aldehydes.The R=t-Bu reagent is sufficiently stable so that it can be us
- Seyfert, Dietmar,Hui, Richard C.
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p. 1473 - 1476
(2007/10/02)
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- Aliphatic Liquid Crystals, 2. Some Nematic Derivatives of all-trans-Perhydrophenanthrene
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A stereoselective synthesis of the all-trans-7-alkylperhydro-2-phenanthrenols 15a-f in 11 steps and 28 liquid crystalline esters 16 of 15a-f are described, additionally some further derivatives of 7-alkylperhydro-2-phenanthrenol.An X-ray structure analysis of ester 16ec is reported.
- Sucrow, Wolfgang,Minas, Hermann,Stegemeyer, Horst,Geschwinder, Peter,Murawski, Hans-Ruediger,Krueger, Carl
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p. 3332 - 3349
(2007/10/02)
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- 2-Heterocyclicalkyl-3,3a,4,5,6,7-hexahydro-3-phenyl-7-(phenylmethylene)-2H-indazoles
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Compounds of the formula STR1 wherein R, X1, X2, A and B are as defined herein, and their N-oxides and acid addition salts thereof, are provided which have been found to possess anti-inflammatory activity. In addition, methods for preparing such compounds, pharmaceutical compositions containing such compounds, and methods for using such compositions as anti-inflammatory agents are also provided.
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- 2-Aminoalkyl-3,3a,4,5,6,7-hexahydro-3-phenyl-7(phenylmethylene)-2H-indazoles
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Compounds of the following formula and their acid addition and quaternary salts and N-oxides SPC1 Wherein X is hydrogen, chloro, fluoro, trifluoromethyl, lower alkyl, or lower alkoxy, R is hydrogen or lower alkyl, A is alkylene of 1 to 8 carbons, and B is --NH2, EQU1 wherein R1 is lower alkyl and R2 is phenyl or phenyl-lower alkyl are disclosed. These compounds are useful as central nervous system depressants.
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