- Synthesis and conformational analysis of macrocyclic dilactones mimicking the pharmacophore of aplysiatoxin
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A small number of macrocyclic dilactones of type 3, i.e., 9, 10, 11, and epi-11, comprising a 3,4-dihydroxypentanoic acid unit, the pharmacophore of aplysiatoxin, and a conformationally preorganized ω-hydroxynonanoic acid unit were synthesized. Conformati
- Knust, Henner,Hoffmann, Reinhard W.
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p. 1871 - 1893
(2007/10/03)
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- Ozonolysis of Enol Ethers. 9. Synthesis and Ozonolysis of 5,6,7,8-Tetrahydrochroman
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The regioselectivity of the transfer of three oxygens of ozone to the olefinic carbons of the rigid substituted enol ether 5,6,7,8-tetrahydrochroman (3) is proved by isolation of ω-caprinolactone 5 instead of an earlier claimed oxacyclodecanone 4.
- Schank, Kurt,Beljan, Petra
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p. 558 - 561
(2007/10/03)
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