- Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors
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The canonical WNT pathway plays an important role in cancer pathogenesis. Inhibition of poly(ADP-ribose) polymerase catalytic activity of the tankyrases (TNKS/TNKS2) has been reported to reduce the Wnt/β-catenin signal by preventing poly ADP-ribosylation-
- Shirai, Fumiyuki,Tsumura, Takeshi,Yashiroda, Yoko,Yuki, Hitomi,Niwa, Hideaki,Sato, Shin,Chikada, Tsubasa,Koda, Yasuko,Washizuka, Kenichi,Yoshimoto, Nobuko,Abe, Masako,Onuki, Tetsuo,Mazaki, Yui,Hirama, Chizuko,Fukami, Takehiro,Watanabe, Hirofumi,Honma, Teruki,Umehara, Takashi,Shirouzu, Mikako,Okue, Masayuki,Kano, Yuko,Watanabe, Takashi,Kitamura, Kouichi,Shitara, Eiki,Muramatsu, Yukiko,Yoshida, Haruka,Mizutani, Anna,Seimiya, Hiroyuki,Yoshida, Minoru,Koyama, Hiroo
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p. 3407 - 3427
(2019/04/17)
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- 4-Hydroxy-2-quinolones 113. Synthesis and antitubercular activity of N-R-amides of 4-hydroxy-6-methyl-2-oxo-1-propyl-1,2,5,6,7,8-hexahydroquinoline- 3-carboxylic acid
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A preparative method has been developed and the synthesis has been effected of anilides and heterylamides of 4-hydroxy-6-methyl-2-oxo-1-propyl-1,2,5,6,7,8- hexahydroquinoline-3-carboxylic acid. A comparative analysis has been carried out of the structure and antitubercular properties of the synthesized compounds and their analogs unsubstituted in the quinoline nucleus.
- Ukrainets,Kolesnik,Sidorenko,Gorokhova,Turov
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p. 326 - 333
(2008/09/21)
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