- Synthesis, antimicrobial and antiproliferative activities, molecular docking, and computational studies of novel heterocycles
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We studied the reaction of enaminone 3 with some nitrogen nucleophiles to afford the corresponding pyrazole 4, isoxazole 5, and pyrimidine 6 derivatives, and the reactivity of enaminone 3 with heterocyclic amines to afford the corresponding fused pyrrolo[
- Fahim, Asmaa M.,Tolan, Hala E. M.,Awad, Hanem,Ismael, Eman H. I.
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p. 2965 - 2981
(2021/05/11)
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- CuI/Cu(OSO2CF3)2 catalysed convenient approach to dichromenopyridines and triazole-thiazole appended chromone derivatives
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A variety of new pentacyclic dichromenopyridines have been synthesized from 2-amino chromone and O-propargyloxy salicilaldehydes through intramolecular Povarov reaction using CuI/Cu(OSO2CF3)2 as a Lewis acid catalyst. The
- Yerrabelly, Jayaprakash Rao,Porala, Subbanarasimhulu,Kasireddy, Venkateshwar Reddy,Ghojala, Venkat Reddy,Rebelli, Pradeep
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p. 3781 - 3790
(2021/11/01)
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- Zn(OTf)2-Catalyzed Formal [3 + 3] Cascade Annulation of Propargylic Alcohols with 2-Aminochromones: Accessing the Chromeno[2,3- b]pyridines
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A Zn(OTf)2-catalyzed formal [3 + 3] cascade annulation strategy for the synthesis of functionalized chromeno[2,3-b]pyridines has been developed using propargylic alcohols and 2-aminochromones as the substrates. The protocol provides a convenien
- Tong, Pei,Sun, Zhou,Wang, Shutao,Zhang, Yuan,Li, Ying
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p. 13967 - 13974
(2019/10/16)
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- Chromenone-rhodamine conjugate for naked eye detection of Al3+ and Hg2+ ions in semi aqueous medium
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Chromenone-rhodamine conjugate 1 has been synthesized and its metal ion binding properties have been studied in CH3CN/water (3:1, v/v; 10?mM HEPES buffer; pH?=?6.85). Compound 1 senses multiple metal ions such as Al3+ and Hg2+/
- Mondal, Subhendu,Bandyopadhyay, Chandrakanta,Ghosh, Kumaresh
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- Synthesis of unsymmetrical 4-oxo-2-vinyl-4H-chromene-3-carbonitrile dyes via Knoevenagel reaction
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New 4-oxo-2-vinyl-4H-chromene-3-carbonitrile derivatives have been synthesized by the Knoevenagel reaction of 2-methyl-4-oxo-4H-chromene-3-carbonitrile with aromatic and heteroaromatic aldehydes. Spectral properties of the obtained compounds have been studied.
- Levchenko,Chudov,Zinoviev,Lyssenko,Demin,Poroshin,Shmelin,Grebennikov
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p. 2788 - 2792
(2018/06/08)
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- A Convenient and Practical Synthesis of Aminopyrazoles
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A selective methodology for preparing highly substituted aminopyrazoles has been demonstrated. Starting with an acetophenol core, the corresponding substituted isoxazole is prepared in two steps. The isoxazole is transformed into a benzopyran. Alkylation
- Mitchell, David,Luo, Yumei,Mcnulty, Lu Anne M.,Buser, Jonas Y.,Mcfarland, Adam D.
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p. 235 - 241
(2015/05/05)
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- Synthesis of new hybrid heterocyclic compounds having 1,2,3-triazole and isoxazole via click chemistry
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A simple and highly efficient method for the regioselective synthesis of isoxazolyl-1,4-disubstituted-1,2,3-triazoles 6a-l in good to excellent yields from terminal alkynes having isoxazole scaffold 4a-c and various azides through Cu(I)-catalyzed 1,3-dipolar cycloaddition is described. The reaction proceeds smoothly in 1:1 mixture of t-BuOH and water at RT. The structures of all newly synthesized hybrid heterocycles are established on the basis of spectral data ir, 1H nmr, mass, and elemental analysis.
- Jayaprakash Rao,Srinivas
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p. 1675 - 1678
(2015/01/09)
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- Facile syntheses of 2-substituted 3-cyanochromones
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A simple and general route to 3-cyanochromones containing various substituents on position 2 of the ring is developed. The method is based on condensation of 3-(2-hydroxyphenyl)-3-oxopropionitrile with acid chlorides or anhydrides in pyridine at room temp
- Levchenko,Semenova,Yarovenko,Shmelin,Krayushkin
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scheme or table
p. 3630 - 3632
(2012/09/22)
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- Synthesis of 2,2′-diaminobischromones using a modified procedure for the rearrangement of 5-(2-hydroxyphenyl)isoxazole to 2-aminochromone
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A modified procedure for the rearrangement of 5-(2-hydroxyphenyl)isoxazoles 6a-e to 2-aminochromones 8a-e was developed and this procedure was utilised in the synthesis of hitherto unreported bischromones 3a-c. The isoxazoles 6a-e were prepared regioselec
- Ghosh, Tarun,Saha, Satyajit,Bandyopadhyay, Chandrakanta
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p. 1845 - 1849
(2007/10/03)
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- A rapid and facile synthesis of isoxazolyl and pyrazolyl phenols from enaminoketones using montmorillonite under heterogeneous catalytic conditions
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A number of isoxazolyl and pyrazolyl phenols (4a-f and 5a-d) have been synthesized from 1-(2-hydroxyaryl)-3-dimethylamino-2-propen-1-ones 3a-f using montmorillonite as solid acid support.
- Jagath Reddy,Srinivasa Rao,Khalilullah,Latha
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p. 1295 - 1297
(2007/10/03)
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- SULPHONYLPIPERIDINE DERIVATIVES CONTAINING AN ARYL OR HETEROARYL GROUP FOR USE AS MATRIX METALLOPROTEINASE INHIBITORS
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A compound of formula (1), wherein B is an ortho substituted monocyclic aryl or heteroaryl group or a bicyclic aryl or heteroaryl group; useful in the inhibition of one or more metalloproteinases, and in particular TACE.
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Page/Page column 47
(2010/02/06)
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- Synthesis of substituted isoxazoles and 1,3,4-oxadiazoles
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A few novel 5-(2'-hydroxyaryl)-isoxazoles 3 and 2-(aryloxymethyl)-3-mercapto-1,3,4-oxadiazoles 8 have been synthesized from the intermediate enamino ketones 2, and tested for their herbicidal activity
- Reddy, Kusukuntla Venkat,Sabitha, G.,Subba Rao, A. V.
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p. 697 - 699
(2007/10/03)
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- The Reaction of S,S-Diphenylsulphilimine with Benzopyran-4-ones and Benzopyran-4-thiones
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Benzopyran-4-ones unsubstituted at carbons 2 and 3 yield aziridines, amines and isoxazoles on treatment with diphenylsulphilimine.The product composition is temperature dependent, aziridines being the major products at room temperature and amines at highe
- Buggle, Katherine,Fallon, Bernadette
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p. 2764 - 2784
(2007/10/02)
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- REACTION OF CHROMONES WITH HYDROXYLAMINE IN ANHYDROUS METHANOL. A NOVEL ROUTE FOR THE PREPARATION OF CHROMONE OXIMES
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The reaction of 4H-1-benzopyran-4-one (chromone, 1) and its substituted derivatives with hydroxylamine in aqueous alcohols gives isoxazoles 5, and 10, as the major products, whereas 1a is transformed mainly into 8a with hydroxylamine hydrochloride in anhydrous methanol; compounds 5a, 9a and 10a can also be isolated, and the formation of 6a and 7a has been detected, as well.Depending on the character of the substituent, substituted chromones 1b-g afforded 7, 8 or 9 as the isolable major product.Based on the present experiments compound 6, produced in an acid-catalyzed methanol addition on 1, is regarded the key intermediate of the formation of chromone oxime
- Szabo, Vince,Borbely, Janos,Theisz, Edit,Nagy, Sandor
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p. 4215 - 4222
(2007/10/02)
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- Reactions with Chromone-3-sulfinic Acid
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Treatment of the title compound 1 with glacial acetic acid/acetic anhydride leads to the thiosulfonate 3, which is hydrolysed to the disulfide 4.Compound 1 reacts with acetone to yield the sulfoxide 5.With formaldehyde the sulfone 7 is formed. 3-Nitrochro
- Loewe, Werner,Eggersmann, Gabriele,Kennemann, Angela
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- Synthesis of Benzopyranoisoxazol-4-ones from 2-Substituted Chromone-3-carboxylic Esters. A Reinvestigation of the Reaction of 3-Acetyl-4-hydroxycoumarins with Hydroxylamine. Synthesis of 4-(2-Hydroxybenzoyl)isoxazol-5-ones
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A convenient method for the synthesis of ethyl 2-substituted chromone-3-carboxylates by the condensation of o-acetoxyaroyl chlorides with β-keto esters is described.These chromones are converted into the corresponding 4H-benzopyranoisoxazol-4-on
- Chantegrel, Bernard,Nadi, Abdel Ilah,Gelin, Suzanne
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p. 4419 - 4424
(2007/10/02)
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- A NEW PATHWAY IN THE REACTIONS OF CHROMONES AND HYDROXYLAMINE IN ANHYDROUS SOLUTIONS
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In the nucleophilic reaction of chromone (1) with NH2OH.HCl in anhydrous methanol a new compound 2-methoxychromanone (6) appeared as an intermediate in the formation of chromone oxime (8) and 2-methoxychromanone oxime (7).
- Szabo, Vince,Borbely, Janos,Theisz, Edit,Janzso, Geza
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p. 5347 - 5350
(2007/10/02)
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- BENZO-γ-PYRONES. PART X. REACTIONS OF DERIVATIVES OF BENZO-γ-PYRONE WITH HYDROXYLAMINE
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The reaction of C-3 (CH3, COOH) and also C-2 and C-3 (CH3) substituted chromone derivatives with hydroxylamine is described.The structures of reaction products (2, 3, 4, 6, 7, 9, 11) were established and some formerly attributed, corrected (9, 10, 11).
- Maib, Piotr,Jerzmanowska, Zofia
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p. 501 - 509
(2007/10/02)
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