Searching new structural scaffolds for BRAF inhibitors. An integrative study using theoretical and experimental techniques
The identification of the V600E activating mutation in the protein kinase BRAF in around 50% of melanoma patients has driven the development of highly potent small inhibitors (BRAFi) of the mutated protein. To date, Dabrafenib and Vemurafenib, two specifi
Campos, Ludmila E.,Garibotto, Francisco M.,Angelina, Emilio,Kos, Jiri,Toma?i?, Tihomir,Zidar, Nace,Kikelj, Danijel,Gonec,Marvanova, Pavlina,Mokry, Petr,Jampilek,Alvarez, Sergio E.,Enriz, Ricardo D.
(2019/08/12)
CARBAMATE QUINABACTIN
The present invention relates to novel sulfonamide derivatives, to processes and intermediates for preparing them, to plant growth regulator compositions comprising them and to methods of using them for controlling the growth of plants, improving plant tolerance to abiotic stress (including environmental and chemical stresses), inhibiting seed germination and/or safening a plant against phytotoxic effects of chemicals.
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Paragraph 0173; 0174
(2018/02/23)
Synthesis of Carbamates Using Yttria-Zirconia Based Lewis Acid Catalyst
A variety of amines react with chloroformates in the presence of catalytic amount of yttria-zirconia based catalyst to afford the corresponding carbamates in excellent yields.
Direct conversion of azides to carbamates and sulfonamides using Fe/NH4Cl: Effect of sonication
A simple, direct and effective conversion of azides to carbamates and sulfonamides is achieved using Fe/NH4Cl in methanol. The influence of sonication and direct application in solution phase combinatorial chemistry are also studied by developing a 6x4 matrix library. (C) 2000 Elsevier Science Ltd.
Chandrasekhar,Narsihmulu
p. 7969 - 7972
(2007/10/03)
Cyclic guanidines. IX. Synthesis of 2-amino-3,4-dihydroquinazolines as blood platelet aggregation inhibitors.
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Ishikawa,Watanabe,Saegusa
p. 1357 - 1364
(2007/10/02)
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