- Preparation method of dobutamine hydrochloride intermediate compound
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The invention discloses a preparation method of a dobutamine hydrochloride intermediate compound. According to the method, 3, 4-dimethoxyphenylethylamine and 4-(4-methoxyphenyl)-2-butanone are adoptedas the starting materials, acetic acid is adopted as a catalyst, cyclohexane is adopted as a reflux water diversion agent, reflux water diversion is performed to obtain a condensation product, potassium borohydride is adopted for further hydrogenation reduction, and hydrochloric acid salification is performed to obtain a crude product of a dobutamine hydrochloride intermediate. Isopropanol is adopted for refluxing and dissolving, an inorganic salt generated in the preparation process of the intermediate is removed through filtering while the solution is hot, and refining is conducted to obtain the dopamine hydrochloride intermediate. According to the method, high-pressure catalytic hydrogenation operation in the prior art is avoided, potential safety hazards are greatly reduced, meanwhile, an expensive metal catalyst is prevented from being used, and the production cost is reduced; and the use of some high-toxicity reagents and genotoxic reagents is avoided.
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Paragraph 0029; 0031; 0033; 0037-0039; 0041; 0045-0047; 0049
(2020/11/02)
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- Direct Access to Isotopically Labeled Aliphatic Ketones Mediated by Nickel(I) Activation
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An extensive range of functionalized aliphatic ketones with good functional-group tolerance has been prepared by a NiI-promoted coupling of either primary or secondary alkyl iodides with NN2 pincer NiII-acyl complexes. The latter were easily accessed from the corresponding NiII-alkyl complexes with stoichiometric CO. This Ni-mediated carbonylative coupling is adaptable to late-stage carbon isotope labeling, as illustrated by the preparation of isotopically labelled pharmaceuticals. Preliminary investigations suggest the intermediacy of carbon-centered radicals.
- Donslund, Aske S.,Pedersen, Simon S.,Gaardbo, Cecilie,Neumann, Karoline T.,Kingston, Lee,Elmore, Charles S.,Skrydstrup, Troels
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p. 8099 - 8103
(2020/03/16)
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- Method for increasing cardiac contractility
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N-Mono or dihydroxyphenylalkyl dopamine derivatives and salts thereof are inotropic agents useful in a method for treatment of acutely depressed cardiac insufficiency.
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