- AIE (AIEE) and mechanofluorochromic performances of TPE-methoxylates: Effects of single molecular conformations
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Two methoxy-substituted tetraphenylethylene (TPE) derivatives, tetra(4-methoxyphenyl)ethylene (TMOE) and tetra(3,4-dimethoxyphenyl)ethylene (TDMOE), were synthesized by McMurry reaction in high yields. The nearly centrosymmetric and natural propeller shape of TMOE and TDMOE excluded intermolecular effects, such as H or J-aggregation and π-π stacking, on their AIE (AIEE) and mechanofluorochromic performance. The crystal structures of TMOE and TDMOE, and theoretical calculations proved that their emission colours are determined by single molecular conjugation. These molecules were used to investigate pure conformational effects on molecular emissions. The spectral properties of these molecules in five environments of crystal(s), THF solution, THF-water binary solution, solidified THF and amorphous states, were investigated. The crystalline to amorphous phase transition by grinding resulted in good mechanofluorochromic performances with high quantum yields and distinguishable emission change, which was further explored as anti-counterfeiting inks on banknotes.
- Qi, Qingkai,Liu, Yifei,Fang, Xiaofeng,Zhang, Yumo,Chen, Peng,Wang, Yi,Yang, Bing,Xu, Bin,Tian, Wenjing,Zhang, Sean Xiao-An
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p. 7996 - 8002
(2013/07/19)
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- Bromophenols as inhibitors of protein tyrosine phosphatase 1B with antidiabetic properties
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A series of bromophenol derivatives were synthesized and evaluated as protein tyrosine phosphatase 1B (PTP1B) inhibitors in vitro and in vivo based on bromophenol 4e (IC50 = 2.42 μmol/L), which was isolated from red algae Rhodomela confervoides
- Shi, Dayong,Li, Jing,Jiang, Bo,Guo, Shuju,Su, Hua,Wang, Tao
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p. 2827 - 2832
(2012/06/01)
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- Inhibition of human carbonic anhydrase isozymes I, II and VI with a series of bisphenol, methoxy and bromophenol compounds
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Carbonic anhydrase inhibitors (CAI) are valuable molecules as they have several therapeutic applications, including anti-glaucoma activity. In this study, inhibition of three human carbonic anhydrase (hCA, EC 4.2.1.1) isozymes I, II and VI with a series o
- Balaydin, Halis Tuerker,Durdagi, Serdar,Ekinci, Deniz,Sentuerk, Murat,Goeksu, Sueleyman,Menzek, Abdullah
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p. 467 - 475
(2012/09/08)
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- Bromophenols as Candida albicans isocitrate lyase inhibitors
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A new series of bromophenols was synthesized by reactions of corresponding phenol analogs with bromine. The synthesized compounds were tested for inhibitory activity against isocitrate lyase (ICL) of Candida albicans and antimicrobial activity against Gram-positive and, Gram-negative bacteria and fungi. Among the synthesized bromophenols, bis(3-bromo-4,5-dihydroxyphenyl) methanone (11) and (3-bromo-4,5-dihydroxyphenyl)(2,3-dibromo-4,5- dihydroxyphenyl)methanone (12) displayed potent inhibitory activities against ICL, showing a stronger inhibitory effects than were found with natural bromophenol 1. The preliminary structure-activity relationships were investigated in order to determine the essential structural requirements for the inhibitory activities of these compounds against ICL of C. albicans.
- Oh, Ki-Bong,Jeon, Heung Bae,Han, Yu-Ri,Lee, Yeon-Ju,Park, Jiyoung,Lee, So-Hyoung,Yang, Dongsik,Kwon, Mihyun,Shin, Jongheon,Lee, Hyi-Seung
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scheme or table
p. 6644 - 6648
(2010/12/19)
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