Tripodal molecules for the promotion of phosphoester hydrolysis
A series of low molecular weight tripodal amide/histidine-containing compounds (1-2) have been synthesised and shown to increase the rate of bis-(p-nitrophenyl) phosphate (BNPP) and soman (GD) breakdown in buffered aqueous solution. This journal is the Partner Organisations 2014.
Hiscock, Jennifer R.,Sambrook, Mark R.,Cranwell, Philippa B.,Watts, Pat,Vincent, Jack C.,Xuereb, David J.,Wells, Neil J.,Raja, Robert,Gale, Philip A.
supporting information
p. 6217 - 6220
(2014/06/09)
Molecular engineering of organophosphate hydrolysis activity from a weak promiscuous lactonase template
Rapid evolution of enzymes provides unique molecular insights into the remarkable adaptability of proteins and helps to elucidate the relationship between amino acid sequence, structure, and function. We interrogated the evolution of the phosphotriesteras
Meier, Monika M.,Rajendran, Chitra,Malisi, Christoph,Fox, Nicholas G.,Xu, Chengfu,Schlee, Sandra,Barondeau, David P.,Hoecker, Birte,Sterner, Reinhard,Raushel, Frank M.
supporting information
p. 11670 - 11677
(2013/09/02)
Visible-light C-heteroatom bond cleavage and detoxification of chemical warfare agents using titania-supported gold nanoparticles as photocatalyst
Gold nanoparticles supported on TiO2 effect the detoxification of soman and VX nerve gases and yperite vesicant agent at room temperature upon visible light illumination.
Neau, Tefan,Cojocaru, Bogdan,Parvulescu, Vasile I.,Omoghi, Vasile,Alvaro, Mercedes,Garcia, Hermenegildo