- Arene Trifunctionalization with Highly Fused Ring Systems through a Domino Aryne Nucleophilic and Diels–Alder Cascade
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A convenient and efficient domino aryne process was developed under transition-metal-free conditions to generate a range of tetra- and pentacyclic ring systems. This transformation was realized via a 1,2-benzdiyne through a nucleophilic and Diels–Alder reaction cascade using styrene as the diene moiety. Three new chemical bonds, namely one C?N and two C?C bonds, and two benzofused rings could be constructed concomitantly, which was made possible by distinct chemoselective control at both the 1,2-aryne and 2,3-aryne stages. Moreover, in-depth studies were carried out on the domino aryne precursors and controlling the diastereoselectivity.
- He, Jia,Jia, Zizi,Tan, Hongcheng,Luo, Xiaohua,Qiu, Dachuan,Shi, Jiarong,Xu, Hai,Li, Yang
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supporting information
p. 18513 - 18518
(2019/11/19)
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- Pyrazolo [4, 3 - h] aminoquin oxazolines and use thereof (by machine translation)
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The invention relates to a kind of the following formula I indicated by the pyrazolo [4, 3 - h] quinazoline derivatives and their use, the compounds inhibit the cell cycle protein dependent enzyme family (CDKs) in different subtype for example CDK4/6 activity, for the prevention and treatment of cancer, metabolic immune diseases, cardiovascular disease and the provision of new means of neurological diseases. (by machine translation)
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Paragraph 0126-0129
(2018/03/01)
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- Titanium(III) chloride mediated synthesis of furan derivatives: Synthesis of (±)-evodone
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Titanocene(III) chloride (Cp2TiCl) mediated one-pot synthesis of furan derivatives has been accomplished. This radical method has been applied for the synthesis of a furanomonoterpene, evodone. Ti(III) species was prepared in situ from commercially available titanocene dichloride (Cp2TiCl 2) and zinc dust in THF. Indian Academy of Sciences.
- Mandal,Paira,Roy
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scheme or table
p. 423 - 426
(2010/12/25)
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- Iron(III) tosylate in the preparation of dimethyl and diethyl acetals from ketones and β-keto enol ethers from cyclic β-diketones
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An efficient method for conversion of ketones to their corresponding dimethyl and diethyl acetals and of cyclic β-diketones into β-keto enol ethers using Fe(OTs)3 as a catalyst is described. Copyright Taylor & Francis Group, LLC.
- Mansilla, Horacio,Afonso, Maria M.
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p. 2607 - 2618
(2008/12/22)
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- The total synthesis of coleophomones B, C, and D
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Members of the coleophomone family of natural products all possess several intriguing and challenging architectural features, as well as exhibit unusual biological activity. They, therefore, constitute attractive targets for synthesis. In this Article, we describe the total synthesis of coleophomones B (2), C (3), and D (4). The highly strained and congested 11-membered macrocycle of coleophomones B (2) and C (3) was constructed using an impressive olefin metathesis reaction. Furthermore, both of the requisite geometric isomers of the Δ within the macrocycle could be accessed from a common precursor, facilitating a divergence that lent the coleophomone B (2)/C (3) synthesis an unusually high degree of efficiency. The synthesis of coleophomone D (4) confirmed that it exists as a dynamic mixture of isomeric forms with a different aromatic substitution pattern from the other family members.
- Nicolaou,Montagnon, Tamsyn,Vassilikogiannakis, Georgios,Mathison, Casey J. N.
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p. 8872 - 8888
(2007/10/03)
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- Iodine-catalyzed synthesis of β-keto enol ethers
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The use of iodine, as a catalyst for the synthesis of β-keto enol ethers at room temperature is reported. The use of iodine, as a catalyst for the synthesis of β-keto enol ethers at room temperature is reported.
- Bhosale, Rajesh S.,Bhosale, Sidhanath V.,Bhosale, Sheshanath V.,Wang, Tianyu,Zubaidha
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p. 7187 - 7188
(2007/10/03)
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- The total synthesis of coleophomones B and C
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Pushing the frontiers of olefin metathesis: As the coleophomones B (1) and C (2) differ only in the configuration of the Δ16,17 double bond, ring-closing metathesis was chosen as the method for their construction following an initially converge
- Nicolaou,Vassilikogiannakis, Georgios,Montagnon, Tamsyn
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p. 3276 - 3281
(2007/10/03)
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- Total synthesis of coleophomone D
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A concise total synthesis of coleophomone D that exists as a dynamic mixture of four isomeric compounds, using a strategy based on a benzoyl cyanide coupling reaction to assemble the key tricarbonyl motif, is reported.
- Nicolaou,Montagnon, Tamsyn,Vassilikogiannakis, Georgios
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p. 2478 - 2479
(2007/10/03)
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- Mild acetalisation of mono and dicarbonyl compounds catalysed by titanium tetrachloride. Facile synthesis of β-keto enol ethers
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The use of TiCl4, as a catalyst for the acetalisation, at room temperature, of carbonyl compounds is reported. Cyclic ketones and cyclic 1,4-diketones easily afford dimethyl acetals, but cyclic 1,3-diketones give β-keto enol ethers. Additionally, aryl ketones and acyclic ketones failed to react. β-keto aldehydes can be monoprotected either as β-keto enol ethers or β-keto dimethyl acetals depending on the reaction time and catalyst amount. Some mechanistic features are accounted for.
- Clerici, Angelo,Pastori, Nadia,Porta, Ombretta
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p. 217 - 225
(2007/10/03)
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- Synthesis and Binding of Simple Neocarzinostatin Chromophore Analogues to the Apoprotein
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Synthetic analogues (3-5, 8-10) of neocarzinostatin chromophore (1) are found to bind to the apoprotein with high affinity.Their binding energies suggest that the naphthoate moiety of 1 is essential for the binding, and that the C5-CH3 and C7-OCH3 groups are necessary for the high affinity.
- Takahashi, Kazunobu,Tanaka, Toshiyuki,Suzuki, Toshio,Hirama, Masahiro
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p. 1327 - 1340
(2007/10/02)
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- A Simple and Efficient Synthesis of the Naphthoate Moiety of Neocarzinostatin Chromophore
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A six-step synthesis of 2-hydroxy-7-methoxy-5-methylnaphthalene-1-carboxylic acid (2), the naphthoate moiety of neocarzinostatin chromophore (1), has been achieved. Key Words: Neocarzinostatin; Chromophore; Synthesis; 2-Hydroxy-7-methoxy-5-methylnaphthalene-1-carboxylic acid
- Takahashi, Kazunobu,Suzuki, Toshio,Hirama, Masahiro
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p. 4603 - 4604
(2007/10/02)
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- A STRATEGY TO 3-ACYL-4-METHYL FURANS. SYNTHESIS OF (+/-)-EVODONE
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Synthesis of Evodone 1 via the radical cyclisation of the bromoacetal 4 to methylene tetrahydrofuran 5 is described.
- Srikrishna, A.,Krishnan, K.
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p. 4995 - 4996
(2007/10/02)
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