- Syntheses of enantiopure aliphatic secondary alcohols and acetates by bioresolution with lipase B from candida antarctica
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The lipase B from Candida antarctica (Novozym 435, CALB) efficiently catalyzed the kinetic resolution of some aliphatic secondary alcohols: (±)-4-methylpentan- 2-ol (1), (±)-5-methylhexan-2-ol (3), (±)-octan-2-ol (4), (±)-heptan-3-ol (5) and (±)-oct-1- en-3-ol (6). The lipase showed excellent enantioselectivities in the transesterifications of racemic aliphatic secondary alcohols producing the enantiopure alcohols (>99% ee) and acetates (>99% ee) with good yields. Kinetic resolution of rac-alcohols was successfully achieved with CALB lipase using simple conditions, vinyl acetate as acylating agent, and hexane as non-polar solvent.
- Ferreira, Hercules V.,Rocha, Lenilson C.,Severino, Richele P.,Porto, Andre L. M.
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p. 8955 - 8967,13
(2020/08/31)
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- Cp2TiCl2-CATALYZED GRIGNARD REACTIONS. 3. REACTIONS WITH ESTERS: EFFICIENT METHODOLOGY FOR THE SYNTHESIS OF SECONDARY ALCOHOLS AND FOR THE REDUCTION OF ESTERS TO PRIMARY ALCOHOLS
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Cp2TiCl2-catalyzed Grignard reactions with esters provide general methodology for preparation of secondary alcohols or for reduction of esters to the corresponding primary alcohols.
- Sato, Fumie,Jinbo, Takamasa,Sato, Masao
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p. 2175 - 2178
(2007/10/02)
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