- Modifications of primaquine as antimalarials. 3. 5-Phenoxy derivatives of primaquine
-
Various 5-phenoxy derivatives of primaquine have been prepared that are somewhat more effective and considerably less toxic that the parent compound in blood and tissue schizonticidal screens. Addition of a methyl group to the pyridine ring of the 5-phenoxyprimaquines has produced a number of antimalarials with potent activity against both blood and tissue schizonts.
- Nodiff,Tanabe,Chen,Saggiomo
-
-
Read Online
- Process for preparing 4-fluoro-3-trifluoromethylphenol
-
Disclosed is a process for preparing 4-fluoro-3-trifluoromethylphenol from 4-fluoro-3-trifluoromethylaniline, which comprises the steps of (1) using about 1 to 20 parts by weight of water based on 1 part by weight of 4-fluoro-3-trifluoromethylaniline in t
- -
-
-
- Preparation of aromatic fluorides: Facile photo-induced fluorinative decomposition of arenediazonium salts and their related compounds using pyridine-nHF
-
By employing pyridine-nHF solution, the photo-induced fluorinative decomposition of arenediazonium salts (ArN2BF4) (fluoro-dediazoniation) and the related compounds, such as quinonediazides and triazenes, has been successfully carried out to produce the corresponding aromatic fluorides (ArF) in good yields. The rate in the fluoro-dediazoniation of para-substituted ArN2BF4 in pyridine-nHF solution did not obey the classical Hammett equation but conformed well to Taft's treatment [dual substituent parameter relationships (DSP)]. In the thermal fluoro-dediazoniation of ArN2BF4 the rate of reaction was significantly influenced by the substituents in the substrates. On the contrary, only a slight effect by the substituents was observed on the rate of the photo-induced fluoro-dediazoniation of ArN2BF4.
- Sawaguchi, Masanori,Fukuhara, Tsuyoshi,Yoneda, Norihiko
-
p. 127 - 133
(2007/10/03)
-
- Facile Preparation of Aromatic Fluorides by the Fluoro-Dediazoniation of Aromatic Diazonium Tetrafluoroborates Using HF-Pyridine Solution
-
The fluoro-dediazoniation of ArN2BF4 using HF-pyridine solution has been successfully carried out either thermaly or photochemically to afford the corresponding ArF in good yields.Particularly, the photochemically induced reaction in HF-pyridine was a useful tool for the preparation of ArF having polar substituents such as halogens, OH, OMe, CF3, etc.
- Fukuhara, Tsuyoshi,Sekiguchi, Manabu,Yoneda, Norihiko
-
p. 1011 - 1012
(2007/10/02)
-