- Homoserine lactone derivatives, preparation method thereof and pharmaceutical composition for prevention or treatment of the periodontal diseases containing the same as an active ingredient
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The present invention relates to homoserine lactone derivatives, optical isomers of the same, or pharmaceutically acceptable salts of the same. The homoserine lactone derivatives in the present invention have excellent properties as a quorum sensing antagonist which hinders communications among bacteria. According to the present invention, the homoserine lactone derivatives can hinder gene expressions of bacteria while effectively blocking formation of biofilm which is known to raise resistance against antibiotics, and suppress propagation of bacteria, thereby being useful as a pharmaceutical composition for preventing or treating periodontal diseases.
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Paragraph 0165-0167
(2017/04/14)
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- Acetic acid aldol reactions in the presence of trimethylsilyl trifluoromethanesulfonate
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(Figure presented) In the presence of TMSOTf and a trialkylamine base, acetic acid undergoes aldol addition to non-enolizable aldehydes under exceptionally mild conditions. Acidic workup yields the β-hydroxy carboxylic acid. The reaction appears to procee
- Downey, C. Wade,Johnson, Miles W.,Lawrence, Daniel H.,Fleisher, Alan S.,Tracy, Kathryn J.
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supporting information; experimental part
p. 5351 - 5354
(2010/10/20)
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- Enzymatic nitrile hydrolysis catalyzed by nitrilase ZmNIT2 from maize. An unprecedented β-hydroxy functionality enhanced amide formation
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To explore the synthetic potential of nitrilase ZmNIT2 from maize, the substrate specificity of this nitrilase was studied with a diverse collection of nitriles. The nitrilase ZmNIT2 showed high activity for all the tested nitriles except benzonitrile, producing both acids and amides. For the hydrolysis of aliphatic, aromatic nitriles, phenylacetonitrile derivatives and dinitriles, carboxylic acids were the major products. Unexpectedly, amides were found to be the major products in nitrilase ZmNIT2-catalyzed hydrolysis of β-hydroxy nitriles. The hydrogen bonding between the hydroxyl group and nitrogen in the enzyme-substrate complex intermediates that disfavors the loss of ammonia and formation of acyl-enzyme intermediate, which was further hydrolyzed to acid, was proposed to be responsible for the unprecedented β-hydroxy functionality assisted high yield of amide formation.
- Mukherjee, Chandrani,Zhu, Dunming,Biehl, Edward R.,Parmar, Rajiv R.,Hua, Ling
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p. 6150 - 6154
(2007/10/03)
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- Indenone synthesis. Improved synthetic protocol and effect of substitution on the intramolecular Friedel-Crafts acylation
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An improved protocol for the construction of substituted indenones is presented. Also the effect of substitution on the intramolecular Friedel-Crafts acylation was noted. Specifically, if there is no substitution at the 2-position of the indenone poor yields of cyclized material were obtained, if at all, while the substitution of a methyl or ethyl group greatly improved the yield of cyclized material. Placement of a large group (e. g., benzyl) resulted in a diminuation of the improved yield. The new synthetic procedure could, in principle, allow for the construction of 2,3-disubstituted indenones. One example of this reaction mode was presented.
- Galatsis, Paul,Manwell, Jeffrey J.,Blackwell, James M.
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p. 1656 - 1659
(2007/10/02)
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- ENANTIOSELECTIVE SYNTHESIS OF α- AND β-HYDROXY ACIDS USING trans-2-PHENYLCYLOHEXAN-1-OL AS CHIRAL AUXILIARY
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trans-2-Phenylcyclohexanol has been used as a chiral auxiliary for the preparation of α- and β-hydroxy acids in 85 - 100 percent and 11 - 89 percent enantiomeric purities respectively.
- Basavaiah, D.,Bharathi, T. K.
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p. 3417 - 3420
(2007/10/02)
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- S-(4-chlorophenyl) 3-aryl-3-hydroxypropanethioates as antibacterial agents
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A series of S-(4-chlorophenyl) 3-aryl-3-hydroxypropanethioates was prepared and shown to have in vitro activity against several selected bacterial species.
- Snyder Jr.,Burrous,Freedman,Herbert
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p. 413 - 415
(2007/10/15)
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- S-(4-Chlorophenyl)-3-aryl-3-hydroxypropanethioates
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A series of S-(4-Chlorophenyl)-3-aryl-3-hydroxypropanethioates are effective as antibacterial agents.
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