Synthesis of a variety of optically active hydroxylated heterocyclic compounds using epoxide hydrolase technology
Novel epoxide hydrolases in Yarrowia lipolytica have been shown to hydrolyse a variety of functionalised epoxides with good to excellent stereoselectivity and at high volumetric productivities. Individual biotransformation products have been converted into optically active (R)-(tetrahydrofuran-2-yl)methanol (6), (S)-N-benzyl-3-hydroxypyrrolidine (7), (S)-3-hydroxytetrahydrothiophene (8), (S)-N-benzyl-3-acetoxypiperidine (10), (S)-3-hydroxytetrahydrofuran (16) and (R)-[(S)-N-benzylpyrrolidin-2-yl](phenyl)methanol (20).
Pienaar, Daniel P.,Mitra, Robin K.,Deventer, Thomas I. van,Botes, Adriana L.
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p. 6752 - 6755
(2009/04/06)
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