- Synthetic routes to a series of proximal and distal 2′-deoxy fleximers
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Two series of innovative 2-deoxy nucleoside analogues have been designed where the nucleobase has been split into its imidazole and pyrimidine subunits. This structural modification serves to introduce flexibility into the nucleobase scaffold while still
- Wauchope, Orrette R.,Velasquez, Melvin,Seley-Radtke, Katherine
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p. 3496 - 3504
(2013/01/15)
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- Nitrogen-containing heterocyclic compounds, their production and use
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A compound of the formula: wherein one of A and D is N and the other is C, or both are N; B is N or C; m is 0-3; R1, R2 and R3 each is (i) H or (ii) a group bound via C, N, O or S; R4 is a group bound via C; R5 is H or a group bound via C or O; R6 is H or a group bound via C; R7 is a homo- or hetero-cyclic group which may be substituted; or a salt thereof possesses excellent gonadotropin-releasing hormone antagonizing activity, and is useful as a prophylactic or therapeutic agent for sex hormone-dependent diseases, and so forth.
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