- ARTIFICIAL METALLOENZYMES CONTAINING NOBLE METAL-PORPHYRINS
-
The present invention is drawn to artificial metalloenzymes for use in cyclopropanation reactions, amination and C—H insertion.
- -
-
Paragraph 0246
(2018/11/21)
-
- Comparison of Phenylacetates with Benzoates and Phenylpropanoates as Antifeedants for the Pine Weevil, Hylobius abietis
-
This study concludes an extensive investigation of antifeedants for the pine weevil, Hylobius abietis (Coleoptera: Curculionidae), an economically important pest of planted conifer seedlings. Building on the previously reported antifeedant effects of benzoates and phenylpropanoids (aromatic compounds with one- or three-carbon-atom substituents on the benzene ring), we here report the antifeedant effects of compounds with two-carbon-atom side chains (i.e., phenylacetates). We also present new results; the best antifeedants from the benzoate class were tested at 10-fold lower concentrations in order to find the optimal antifeedants. Generally, for all three compound classes, efficient antifeedants were found to have one or two methyl, chloro, or methoxy substituents on the aromatic ring. For monosubstituted phenylpropanoids, the substituent preferably should be in the para-position. In the search for synergistic antifeedant effects among the three compound classes, combinations of compounds from the three classes were tested in binary and ternary mixtures.
- Unelius, C. Rikard,Bohman, Bj?rn,Nordlander, G?ran
-
p. 11797 - 11805
(2018/11/21)
-
- Synthesis of Psoralidin derivatives and their anticancer activity: First synthesis of Lespeflorin I1
-
Synthetic scheme for the preparation of a number of different derivatives of anticancer natural product Psoralidin is described. A convergent synthetic approach is followed using simple starting materials like substituted phenyl acetic esters and benzoic acids. The developed synthetic route leads us to complete the first synthesis of an analogous natural product Lespeflorin I1, a mild melanin synthesis inhibitor. Preliminary bioactivity studies of the synthesized compounds are carried out against two commonly used prostate cancer cell lines. Results show that the bioactivity of the compounds can be manipulated by the simple modification of the functional groups.
- Pahari, Pallab,Saikia, Ujwal Pratim,Das, Trinath Prasad,Damodaran, Chendil,Rohr, Jürgen
-
supporting information
p. 3324 - 3334
(2016/05/19)
-
- A straightforward organocatalytic alkylation of 2-arylacetaldehydes: An approach towards bisabolanes
-
A highly stereoselective organocatalytic aalkylation of 2-arylacetaldehydes with a commercially available carbenium tetrafluoroborate is described. The stereoselective alkylation was carried out in acetonitrile/ water, under air in the presence of a commercially available imidazolidinone (MacMillan's catalyst). Key intermediates for the synthesis of bisabolanes were obtained through a simple chemistry. In particular a direct, enantioselective and facile synthesis of (R)-(-)-curcumene is described.
- Gualandi, Andrea,Canestrari, Pietro,Emer, Enrico,Cozzi, Pier Giorgio
-
supporting information
p. 528 - 536
(2014/05/20)
-
- Synthesis, urease inhibition, antioxidant and antibacterial studies of some 4-Amino-5-aryl-3H-1,2,4-triazole-3-thiones and their 3,6-Disubstituted 1,2,4-Triazolo[3,4-b]1,3,4-thiadiazole derivatives
-
A new series of 4-amino-5-aryl-3H-1,2,4-triazole-3-thiones, bearing various methoxybenzyl- and methoxyphenethyl groups, was synthesized by refluxing potassium hydrazinecarbodithioate salts in dilute aqueous solution of hydrazine hydrate. These salts were formed by the reaction of acid hydrazides and carbon disulfide in methanolic potassium hydroxide solution at 0-5 °C. 4-Amino-5-aryl-3H-1,2,4-triazole-3-thiones were condensed with different substituted aromatic acids to yield 3,6-disubstituted-1,2,4-triazolo[3,4-b]1,3, 4-thiadiazoles. The structures of the synthesized compounds were characterized by infrared (IR), 1H and 13C nuclear magnetic resonance (NMR), elemental analysis and mass spectrometric (MS) studies. All the synthesized compounds were screened for their urease inhibition, antioxidant and antibacterial activities. Some compounds showed excellent urease inhibition activity, more than the standard drug. Others exhibited potent antioxidant activity. All the compounds showed significant antibacterial activities as compared to the standard drug.
- Hanif, Muhammad,Saleem, Muhammad,Hussain, Muhammad Tahir,Rama, Nasim Hasan,Zaib, Sumera,Aslam, Muhammad Adil M.,Jones, Peter G.,Iqbal, Jamshed
-
experimental part
p. 854 - 860
(2012/07/28)
-
- 1-(PIPERIDIN-4-YL)-1H-INDOLE DERIVATIVE
-
The present invention provides a compound represented by the formula (1) or a pharmacologically acceptable salt thereof, or a hydrate thereof (provided that a compound in which all of R4a, R4b, and R4c are hydrogen atoms is excluded.): [wherein R1 represents a hydrogen atom, R2 represents a hydrogen atom, R3 represents the formula: wherein R4a, R4b, and R4c are the same as or different from each other and each represents a hydrogen atom, a C1-6 alkyl group or a C1-6 alkoxy group, etc.]
- -
-
Page/Page column 58
(2010/11/28)
-
- Synthesis of homogentisic acid by carbonylation
-
The synthesis of homogentisic acid by carbonylation of 2,5-dihydroxybenzyl chloride derivative followed by hydrolysis is discussed.
- Prasad, Chalasani S N,Adapa, Srinivas R
-
p. 626 - 627
(2007/10/02)
-
- PHASEOLOIDIN, A HOMOGENTISIC ACID GLUCOSIDE FROM ENTADA PHASEOLOIDES
-
The structure of phaseoloidine isolated from the seeds of Entada phaseolides has been determined as homogentisic acid 2-O-β-D-glucopyranoside by chemical and spectral means.
- Barua,, Arun K.,Chakrabarty, Manas,Datta, Pran K.,Ray, Sarmila
-
p. 3259 - 3262
(2007/10/02)
-
- EFFECT OF STRUCTURE ON PHOTOALCOHOLYSIS OF AROMATIC α-HALOKETONES
-
Desyl halide, α-bromophenylacetate, and 2,5-dimethoxy-α-bromoacetophenones undergo smooth photomethanolysis, whereas simple α-bromoacetophenone undergoes photoreduction to give acetophenone.
- Izawa, Yasuji,Watoh, Yasushi,Tomioka, Hideo
-
-
- SYNTHESIS AND PROPERTIES OF A SERIES OF LINKED PORPHYRIN-QUINONE MOLECULES DESIGNED AS MODELS OF THE REACTION CENTRE IN PHOTOSYNTHESIS
-
The synthesis of the covalently linked porphyrin-quinone compounds 4a, 4b, and 4c is described.The structures of the linked compounds and their precursors in the synthetic route are established by ultraviolet/visible absorption spectroscopy, 1H
- Ho, Te-Fu,McIntosh, Alan R.,Weedon, Alan C.
-
p. 967 - 974
(2007/10/02)
-
- Syntheses of Covalently-Linked Porphyrin-Quinone Complexes (1)
-
A synthetic route for the preparation of covalently-linked porphyrin-quinone and metalloporphyrin-quinone complexes as models for the phototrap in bacterial photosynthesis is described. 5-(4-Carboxyphenyl)-10,15,20-tritolylporphyrin, prepared by a mixed aldehyde approach, was attached to a benzoquinone center with a propanediol bridge by means of ester linkages.The starting point for the benzoquinone moiety was 2,5-dihydroxyphenylacetic acid, whose hydroquinone function was first protected by preparing its dimethylether.The spacing between the two centers of the complex could be altered simply by varying the length of the bridging group (a diol) employed.Boron tribromide was used to unmask the quinol derivatives in the final coupled products.The zinc(II) derivative of porphyrin quinone comple was prepared ba addition of a saturated solution of zinc acetate in methanol to a solution of the corresponding porphyrin-hydroquinone complex in dichloromethane at room temperature.The structures of these complexes were confirmed by nmr spectroscopy, uv-visible absorption, and mass spectroscopy.Oxidation of the quinol moiety in the covalently-linked complex to its corresponding quinonoid derivative was accomplished by treating a solution of the complex in dichloromethane with a stoichiometric amount of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone, a high potential benzoquinone.
- Kong, Josephine L. Y.,Loach, Paul A.
-
p. 737 - 744
(2007/10/02)
-