- Synthesis, characterization and biological evaluation of some newer carbazole derivatives
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A series of novel 5-[(9H-carbazol-9-yl)methyl]-N-[(substituted phenyl)( piperazin-1-yl)methyl]-1,3,4-oxadiazol-2-amines (4a-o) derivatives was synthesized by starting with carbazole, which on reaction with ethyl chloroacetate yielded ethyl 2-(9H-carbazole
- Sharma, Divyanshu,Kumar, Nitin,Pathak, Devender
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- Metal ion clip: Fine-tuning aromatic stacking interactions in the multistep formation of carbazole-bridged zinc(ii) complexes
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A carbazole-based triple bridging ligand (LH) consisting of two imidazole moieties at 3,6 positions with a diketone unit at the carbazole nitrogen forms carbazole-bridged zinc(ii) complexes with structures of [(L-)4(Zn2+)
- Imai, Yuki,Kawai, Tsuyoshi,Yuasa, Junpei
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- OFF-ON-OFF Dual Emission at Visible and UV Wavelengths from Carbazole Functionalized β-Diketonate Europium(III) Complex
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This work demonstrates dual emission "OFF-ON-OFF" switching at visible and UV wavelengths of a carbazole functionalized β-diketone (LH) by a simple change of a europium(III) ion (Eu3+) concentration in the submicromolar concentration range. In
- Imai, Yuki,Kawai, Tsuyoshi,Yuasa, Junpei
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- Carbazole oxadiazole conjugates, and preparation method and application thereof
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The invention relates to carbazole oxadiazole conjugates, and a preparation method and an application thereof, and belongs to the technical field of chemical synthesis. The carbazole oxadiazole conjugates are represented by general formula I. The above co
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Paragraph 0042-0044
(2019/10/23)
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- Carbazole-isatin type compound and preparation method and application thereof
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The invention discloses a carbazole-isatin type compound and a preparation method and application thereof.The compound is of a structure as shown in a formula (I), and the preparation method comprises the steps of using carbazole and ethyl bromoacetate as raw materials to obtain 2-(9H-carbazole-9-yl) ethyl acetate, then performing hydrazinolysis reaction to obtain 2-(9H-carbazole-9-yl) acethydrazide, and finally performing reaction with various types of substitutive isatin to obtain a target compound.The compound can serve as a raw material for anti-tumor drugs, the raw materials for the preparation method are simple and easy to obtain, and operation is convenient.
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Paragraph 0010
(2016/10/08)
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- Substituted Carbazoles-A New Class of Anthelmintic Agent
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A series of novel carbazoles were synthesized based on structural modifications to lead carbazole 1 (EC100≤2.5M against Haemonchus contortus in vitro), which was revealed in a small molecule screening program as a potentially promising platform for the development of new anthelmintic drugs. Subsequently, analogues 19, 21, 41, 42 (EC100≤ 1.25M, all), and 39 (EC100≤0.625M) were demonstrated to exhibit enhanced in vitro anthelmintic activity over the lead structure, with compound 39 also being shown to be active in vivo against Heligmosomoides polygyrus.
- Rennison, David,Gueret, Stephanie M.,Laita, Olivia,Bland, Ross J.,Sutherland, Ian A.,Boddy, Ian K.,Brimble, Margaret A.
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p. 1268 - 1276
(2016/11/25)
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- Unveiling photodeactivation pathways for a new iridium(III) cyclometalated complex
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We report the synthesis and characterization of a neutral heteroleptic IrIII complex bearing 6-fluoro-2-phenylbenzo[d]thiazole as cyclometalating ligand and (Z)-6-(9H-carbazol-9-yl)-5-hydroxy-2,2-dimethylhex-4- en-3-one as ancillary ligand. The
- Escudero, Daniel,Heuser, Eike,Meier, Robert J.,Schaeferling, Michael,Thiel, Walter,Holder, Elisabeth
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p. 15639 - 15644
(2013/11/19)
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- Solid-liquid phase alkylation of n-heterocycles: Microwave-assisted synthesis as an environmentally friendly alternative
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The solid-liquid phase alkylation of a variety of five-membered N-heterocycles (carbazole, imidazole, benzimidazole, and indole-3-carbaldehyde) was carried out under different conditions. The use of alkali carbonate in dimethylformamide or in MeCN (in the latter case, in the presence of a phase-transfer catalyst) is a suitable method to prepare the corresponding N-alkylated products in an efficient way. In most cases, the solventless, microwave-assisted reaction is an environmentally friendly alternative to traditional methods. Copyrigh
- Milen, Matyas,Gruen, Alajos,Balint, Erika,Dancso, Andras,Keglevich, Gyoergy
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experimental part
p. 2291 - 2301
(2010/09/17)
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- Synthesis and characterization of six new carbazolyl porphyrins
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Novel 4-(N-carbazole methyl) benzoic acid and N-carbazolacetic acid are synthesized, then six new carbazolyl porphyrins are synthesized by bonding these acids to hydroxy porphyrin or amido porphyrin via acyl chloride or N,N'-dicyclohexylcarbodiimide (DCC)
- Guo, Dong-Cai,Li, Ping-Liang,Wang, Xin,Wang, Li-Ying,Wu, Pan-Liang
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experimental part
p. 3315 - 3321
(2011/01/04)
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- Cyclometalated red iridium(iii) complexes containing carbazolyl- acetylacetonate ligands: Efficiency enhancement in polymer LED devices
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The design, synthesis, photophysical and significantly improved electrooptical properties of a series of red emitting cyclometalated iridium(iii) complexes containing carbazolyl-acetylacetonate ligands are described.
- Tian, Nan,Aulin, Yaroslav V.,Lenkeit, Daniel,Pelz, Simon,Mikhnenko, Oleksandr V.,Blom, Paul W. M.,Loi, Maria Antonietta,Holder, Elisabeth
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scheme or table
p. 8613 - 8615
(2011/01/10)
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- Synthesis and antipsychotic and anticonvulsant activity of some new substituted oxa/thiadiazolylazetidinonyl/thiazolidinonylcarbazoles
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A novel substituted oxa/thiadiazolylazetidinonyl/thiazolidinonylcarbazoles (4a-j), (5a-j) and (6a-j) were synthesized and screened for their antipsychotic and anticonvulsant activities. It is concluded from the results compound 6j showed promising antipsy
- Kaur, Hemlata,Kumar, Sunil,Vishwakarma, Pinki,Sharma, Monica,Saxena,Kumar, Ashok
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experimental part
p. 2777 - 2783
(2010/08/22)
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- 3-Aminocarbozole compound, pharmaceutical composition containing it and preparation method therefor
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The present invention relates to novel benzoyl derivatives of 3-aminocarbazole, to a pharmaceutical composition containing them, to a method for preparing them and to the use of such compounds for the production of a drug that is useful in the treatment o
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Page/Page column 9-10
(2009/12/05)
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- Use of ion channel modulating agents
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The present invention relates to the use of a particular class of chemical compounds as modulators of SKCa, IKCa and BKCa channels, and to pharmaceutical compositions comprising the SK/IK/BK channel modulating agents.
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- Synthesis of 2-aryl-3-(N9-carbazolylacetamidyl)-4-oxothiazolidines and their 5-arylidenes as antifungal and analgesic agents
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Several 2-aryl-3-(N9-carbazolylacetamidyl)-4-oxothiazolidines (4) and 2-aryl-3-(N9-carbazolylacetamidyl)-5-arylidene-4-oxothiazolidines (5) have been synthesised and tested for their antifungal and analgesic activities.
- Srivastava,Srivastava,Srivastava
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p. 320 - 322
(2007/10/03)
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- Synthesis of new carbazolyl-thiadiazol-2-oxo-azetidines : Antimicrobial, anticonvulsant and anti-inflammatory agents
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Several 2-arylidenylamino-5- (carbazolylmethyl)-1,3,4-thiadiazoles 4 and 1-[5'-(carbazolylmethyl)-1', 3', 4'-thiadiazol-2'-yl)]-4-(substituted phenyl)-3-chloro-2-oxo-azetidines 5 have been synthesised and evaluated for their antimicrobial, anticonvulsant
- Srivastava,Srivastava,Srivastava
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p. 183 - 187
(2007/10/03)
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- Synthesis of 2-(substituted aryl)-3-(N9-carbazolylacetamidyl)-4-oxothiazolidines and their 5-arylidine derivatives as antifungal agents
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Several 2-(substituted aryl)-3-(N9-carbazolylacetamidyl)-4-oxo-thiazolidines 4 and 2-(substituted aryl)-3-(N9-carbazolylacetamidyl)-5-arylidine-4-oxo-thiazolidines 5 have been synthesized and tested for their antifungal activity. The
- Lodhi, R. S.,Srivastava, S. D.
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p. 947 - 950
(2007/10/03)
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- Synthesis of some new aryl &α-3-substituted-carbazol-9-yl)acetates/propionates as possible antiinflammatory and analgesic agents
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Several novel phenyl/substituted phenyl esters of 9-(3-substituted-carbazolyl)acetic/propionic acids have been synthesized and screened for antiinflammatory and analgesic activity.
- Shukla, Yogendra K.
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p. 799 - 802
(2007/10/03)
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- Reactivity of a tetrahedral Intermediate in Hydrolysis of N-Acetylpyrrole
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Base hydrolysis of N-acetylpyrrole (1a) involves formation of an anionic tetrahedral intermediate (2a).The equilibrium constant between these two species can be estimated by extrapolation based on the equilibrium constants for hydration of N-trichloroacetyl and N-trifluoroacetylpyrrole and the estimated pKa for deprotonation of the hydrates of these compounds.Inductive effects upon hydration and deprotonation of the hydrates were estimated by analogy with inductive effects upon the equilibrium reactions of chloral and acetaldehyde.The free energies of activation for formation and return of 2a are approximately 16 and 12.5 Kcal mole-1 respectively and for conversion of 2a to products 11 Kcal mole-1 in aqueous 1M OH-.
- Cipiciani, Antonio,Savelli, Gianfranco,Bunton, Clifford A.
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p. 975 - 976
(2007/10/02)
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