[5C + 1N] Annulation of 2,4-pentadienenitriles with hydroxylamine: A synthetic route to multi-substituted 2-aminopyridines
A facile and efficient synthetic route to multi-substituted 2-aminopyridines has been developed via a formal [5C + 1N] annulation of readily available 2,4-pentadienenitriles with hydroxylamine (NH2OH) under very mild conditions, which involves
A New Route to 2-Amino- or 2-Hydroxy-3-pyridinecarboxylic Acid Derivatives
Schiff's bases derived from ketones and t-butylamine (1) reacted with methyl methoxymethylenemalonate to give 2-hydroxy-3-pyridinecarboxylates.Similarly, treatment of 1 with ethoxymethylenemalononitrile gave 2-amino-3-pyridinecarbonitriles.Compounds 1 on reaction with ethyl 2-cyano-3-ethoxypropenoate afforded 2-amino-3-pyridinecarboxylates.
Ito, Kunio,Yokokura, Seiichi,Miyajima, Shingo
p. 773 - 778
(2007/10/02)
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