Synthesis and antidyslipidemic activity of chalcone fibrates
A series of chalcone based PPAR-α agonists were synthesized and evaluated for their antidyslipidemic activity in high fructose high fat fed dyslipidemic Syrian golden hamsters. Most of the compounds exhibited antidyslipidemic activity. The compounds 4c an
The present invention encompasses compounds of the formula STR1 wherein R1 and R2 are independently an alkyl radical containing from 1 to 2 carbon atoms and R3 is hydrogen or an alkyl radical containing from 1 to 7 carbon atoms, sodium, potassium, or ammonium cation. The compounds of the present invention are prepared by the condensation of alkyl(4-formylphenoxy)-2,2-dialkylacetate with acetophenone in basic medium. These compounds are potent hypolipemic agents as well as antifungal and antibacterial agents.
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(2008/06/13)
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