A one-pot, water compatible synthesis of pyrimidine nucleobases under plausible prebiotic conditions
Herein, we report a new prebiotically plausible pathway towards a pyrimidine nucleobase in continuous manner. The route involves simultaneous methylation and carbamoylation of cyanoacetylene-derived α,β-unsaturated thioamide with N-methyl-N-nitrosourea (MNU) in aqueous media. This provides S-methylpyrimidinone in one-pot, which can be converted into a variety of 4-substituted pyrimidine nucleobases including cytosine and uracil.
Okamura, Hidenori,Becker, Sidney,Tiede, Niklas,Wiedemann, Stefan,Feldmann, Jonas,Carell, Thomas
PHOTOCHEMICAL SYNTHESIS OF N4-SUBSTITUTED CYTOSINES
The convenient method for the preparation of N4-substituted cytosines is described.The irradiation with UV light of N-(1H-2-oxo-4-pyrimidinyl)amino acids provides the proper N4-substituted cytosines in a good yield.
Celewicz, Lech,Spychala, Jaroslaw,Golankiewicz, Krzysztof
p. 1939 - 1950
(2007/10/02)
More Articles about upstream products of 6220-47-9