- Ruthenium(II)-catalyzed arylation of ortho-CH Bonds in 2-aroyl-imidazoles with aryl halides
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The ruthenium(II)-catalyzed ortho-CH arylation of 2-aroyl-imidazoles with aryl bromides and chloride is reported. An imidazole ring functions both as a masked ester and a directing group for CH activation. A variety of functional groups are tolerated unde
- Wang, Chen-An,Chatani, Naoto
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supporting information
(2021/04/23)
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- Base-Promoted Amidation and Esterification of Imidazolium Salts via Acyl C-C bond Cleavage: Access to Aromatic Amides and Esters
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Imidazolium salts have been effectively employed as suitable acyl transfer agents in amidation and esterification in organic synthesis. The weak acyl C(O)-C imidazolium bond was exploited to generate acyl electrophiles, which further react with amines and alcohols to afford amides and esters. The broad substrate scope of anilines and benzylic amines and base-promoted conditions are the benefits of this route. Interestingly, phenol, benzylic alcohols, and a biologically active alcohol can also be subjected to esterification under the optimized conditions.
- Karthik, Shanmugam,Muthuvel, Karthick,Gandhi, Thirumanavelan
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supporting information
p. 738 - 751
(2019/01/24)
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- A new and highly efficient water-soluble copper complex for the oxidation of secondary 1-heteroaryl alcohols by tert-butyl hydroperoxide
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The water-soluble copper complex generated in situ from CuCl2 and 2,2′-biquinoline-4,4′-dicarboxylic acid dipotassium salt (BQC), has been revealed as a highly efficient and selective catalyst for the oxidation of secondary 1-heteroaryl alcohols to the corresponding heteroaromatic ketones with aqueous tert-butyl hydroperoxide, under mild conditions. The catalytic system is compatible with different heterocycles such as pyridines, pyrroles, indoles, thiophens, furans, thiazoles, and imidazoles.
- Boudreau, Josée,Doucette, Mike,Ajjou, Abdelaziz Nait
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p. 1695 - 1698
(2007/10/03)
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