Palladium-catalyzed cascade process to construct 1,2,5-trisubstituted pyrroles
A novel palladium-catalyzed cascade allylic amination/intramolecular hydroamination/isomerization process of protected enynol 1 and primary amine 2 has been explored, which constructs the important 1,2,5-trisubstituted pyrroles. This transformation offers an alternative synthetic methodology capable of generating substituted pyrroles in a straightforward way.
Formation of 1- and 2-Alkoxyenynes in Palladium-Catalyzed Cross-Coupling of 1- and 2-Bromoalkenyl Alkyl Ethers with Alkynes
A preparative route to 1- and 2-alkoxyenynes is developed on the basis of stereoselective cross-coupling of 1- and 2-haloalkenyl alkyl ethers with terminal alkynes in the presence of palladium catalyst. Hydrolysis of 1- and 2-alkoxyenynes yields carbonyl derivatives containing a triple bond: substituted acetaldehyde and ketone, respectively.