- The synthesis and biological evaluation of nucleobases/tetrazole hybrid compounds: A new class of phosphodiesterase type 3 (PDE3) inhibitors
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Spired by the chemical structure of Cilostazol, a selective phosphodiesterase 3A (PDE3A) inhibitor, several novel hybrid compounds of nucleobases (uracil, 6-azauracil, 2-thiuracil, adenine, guanine, theophylline and theobromine) and tetrazole were designe
- Shekouhy, Mohsen,Karimian, Somaye,Moaddeli, Ali,Faghih, Zeinab,Delshad, Yousef,Khalafi-Nezhad, Ali
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- Nucleosides 9: Design and synthesis of new 8-nitro and 8-amino xanthine nucleosides of expected biological activity
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The coupling reaction of 1,3-dimethylxanthine (theophylline), 3-benzylxanthine and 3-benzyl-1-methylxanthine with 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose afforded the corresponding protected nucleosides, respectively. Nitration of each of the theo
- Mohamed, Mosselhi A. N. M.,Abu-Alola, Laila M. B.,Aljaied, Nada M. G.
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p. 745 - 756
(2017/12/26)
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- Silica sulfuric acid (SSA) as a highly efficient heterogeneous catalyst for persilylation of purine and pyrimidine nucleobases and other N-heterocycles using HMDS
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Purine and pyrimidine nucleobases and other N-heterocycles have been silylated with HMDS in excellent yields in the presence of a catalytic amount of silica sulfuric acid (SSA) as a heterogeneous catalyst. SSA utilizes a shorter reaction time and higher yields of silylated nucleobases. SSA is reusable for several times without a decrease in reactivity or yield of silylated adducts. Copyright
- Rad, Mohammad Navid Soltani,Khalafi-Nezhad, Ali,Divar, Masoumeh,Behrouz, Somayeh
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experimental part
p. 1943 - 1954
(2010/11/16)
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- Synthesis of Theophylline and 6-Thiotheophylline 7-Ribosyl Nucleosides
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The syntheses of theophylline and thiotheophylline 7-ribopyranose and 7-ribofuranose nucleosides, both by direct coupling of the base and the sugar and by construction of the imidazole ring, are reported. The conformational syn/anti equilibrium of the peracetyl derivatives was studied by molecular mechanics and by the low-temperature line-shape/1H NMR method. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.
- Rico-Gomez, Rodrigo,Rodriguez-Gonzalez, Angel,Rios-Ruiz, Josefa,Najera, Francisco,Manuel Lopez-Romero
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p. 4023 - 4032
(2007/10/03)
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