- Synthesis of 2'-arylazabicyclo-3-spiro-4'(5')-imidazolines
-
A method is described for the synthesis of a series of 2'-aryl-3-azabicyclospiro-4'(5')-imidazolines via the reaction of azabicyclic 1,2-diamines with aryl imidate salts. Competing reactions in the synthesis of the diamines such as the reduction of amino nitriles with LiAlH4 lead to some anomalous products. In the Pinner synthesis, unstable pyridine-type imidates were stabilized as their N-oxide derivatives.
- Whelan,Iriepa,Galvez
-
p. 832 - 836
(2007/10/02)
-
- Fused imidazoheterocyclic compounds and pharmaceutical compositions
-
Imidazoheterocyclic compounds having the formula: STR1 wherein the A ring is pyridine in any of its four positions; B is carbonyl, thioxomethyl or hydroxymethylene; Z is hydrogen, halogen, loweralkyl, hydroxy, loweralkoxy, diloweralkylamino or nitro; Ar i
- -
-
-
