Halocyclization of Unsaturated Alcohols and Carboxylic Acids Using Bis(sym-collidine)iodine(I) Perchlorate
Reaction of I(collidine)2(1+) ClO4(1-) with unsaturated alcohols and carboxylic acids in dichloromethane at ambient temperature has afforded three- to seven-membered-ring iodoethers and four- to seven-membered-ring iodolactones, respectively, in moderate
Evans, Robert D.,Magee, Joseph W.,Schauble, J. Herman
p. 862 - 868
(2007/10/02)
Facile one-pot transformation of carboxylic acid chlorides into 2-substituted allyl alcohols
The reaction of carboxylic acid chlorides (1) with chloromethyl-lithium generated in situ (1:2 molar ratio) in the presence of lithium iodide leads, after hydrolysis, to the corresponding homologated 2-substituted allyl alcohols (2).
Barluenga, Jose,Concellon, Jose M.,Fernandez-Simon, Jose L.,Yus, Miguel