- Synthesis and in vitro and in silico studies of 1H- and 2H-1,2,3-triazoles as antichagasic agents
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1,2,3-triazole heterocycles stand out in medicinal chemistry for having great structural diversity and bioactivities. In this study, two series of triazoles were synthesized. One was obtained by the 1,3-dipolar cycloaddition reaction between ethyl cyanoac
- Silva, Thais B.,Ji, Kathya N.K.,Petzold Pauli, Fernanda,Galv?o, Raíssa M.S.,Faria, Ana F.M.,Bello, Murilo L.,Resende, Jackson A.L.C.,Campos, Vinicius R.,Forezi, Luana da S.M.,da Silva, Fernando de C.,Faria, Robson X.,Ferreira, Vitor F.
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- Studies on v-Triazoles. Part I: Synthesis of 4,9-Dihydro-9-oxo-1H-v-triazolo quinolines by cyclization of 5-arylamino-v-triazole-4-carboxylic acids with polyphosphoric acid.
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The cyclization of 5-arylamino-v-triazole-4-carboxylic acids with polyphosphoric acid leads to high yields of the corresponding 4,9-dihydro-9-oxo-v-triazolo quinolines which are potent antiallergic agents.
- Buckle, Derek R.
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p. 3870 - 3874
(2007/10/02)
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- Triazolo [4,5-b] quinolines and prophylaxis of allergic diseases with them
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The invention provides novel compounds of formula (I). STR1 and pharmaceutically acceptable salts thereof wherein R1, R2, R3 and R4 which may be the same or different, represent hydrogen, halogen, lower alkyl, and lower alkoxy, or any adjacent two of R1 to R4 taken together represent an alkylene group containing from 3 to 5 carbon atoms or a 1,4-buta-1,3-dienylene group. The compounds are useful as anti-allergic agents.
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