- An Improved Procedure for the Synthesis of Prostaglandin Analogues
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Hydrozirconation-iodination of a terminal acetylene followed by lithium-iodide exchange and finally dilithio cyanocuprate mediated conjugate addition to an appropriate cyclopentenone is reported as an efficient method for the synthesis of prostaglandin analogues.
- Kalish, Vincent J.,Shone, Robert L.,Kramer, Steven W.,Collins, Paul W.,Babiak, Kevin A.,et al.
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p. 1641 - 1645
(2007/10/02)
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- 1-Hydroxymethyl-1-1-oxo prostane derivatives of the E and F series
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The invention disclosed herein relates to pharmacologically active prostaglandin derivatives of the E, F, or A series having on the terminal methylene carbon of the alpha chain a substituent selected from the group consisting of: STR1 wherein R is an alkyl group and R15 is C1 -C4 alkyl, C1 -C4 alkoxy, di-C1 -C4 -alkylamino, and phenyl orphenyl substituted with one or more substituents selected from the group consisting of C1 -C4 alkyl, OR, SR, F, or Cl wherein R is as previously defined.
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- 1-Substituted-1-oxo-prostane-derivatives of the E, A and F series
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The invention disclosed herein relates to pharmacologically active prostaglandin derivatives of the E, F, or A series having on the terminal methylene carbon of the alpha chain, a substituent selected from the group consisting of: STR1 wherein R is C1 to C6 alkyl, and phenyl or phenyl substituted with one or more substituents selected from the group consisting of C1 -C4 alkyl, OR16, SR16, F, or Cl, and R16 is C1 to C6 alkyl.
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- 11-(2-Hydroxyethylthio) prostenoic acid E and F series derivatives
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This disclosure describes certain 11-(2-hydroxyethylthio) prostenoic acid E and F series derivatives, and their intermediates, useful as bronchodilators and inflammatory medeator release inhibitors.
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- 1-Hydroxymethyl-1-oxo-prostane derivatives of the E2 series
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Derivatives, analogs, and congeners of prostane having a 1-(hydroxymethyl)-1-oxo-prostane structure in the E2 series.
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- Novel 16 hydroxy 15-deoxy-5-cis-prostenoic acids and esters
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This disclosure describes certain hydroxy substituted 15-deoxy-5-cis-prostenoic acids and esters useful as hypotensive agents, anti-ulcer agents, bronchodilators, anti-microbial agents, anticonvulsants, or as intermediates.
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- 11-(2-Hydroxyethylthio)prostenoic acid E2 series derivatives
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This disclosure describes certain 11-(2-hydroxyethylthio)-9-keto-prostenoic acid E series derivatives, and their intermediates, useful as bronchodilators and inflammatory medeator release inhibitors.
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- 7-{3-Hydroxy-2β-[4-hydroxy-4-(lower alkyl)-trans-1-octen-1-yl]-5-oxocyclopent-1α-yl}hept-5-cis-enoic acids and related compounds
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7-{3-Hydroxy-2β-[4-hydroxy-4-(lower alkyl)-trans-1-octen-1-yl]-5-oxocyclopent-1α-yl}hept-5-cis-enoic acids, displaying valuable pharmacological properties, e.g., gastric anti-secretory, are produced by the reaction of 7-(3-oxygenated-5-oxocyclopent-1-en-1-yl)hept-5-cis-enoic acid or ester with the appropriate organometallic reagent.
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