- Synthesis method 7- aminoheptanoic acid hydrochloride
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The invention discloses a synthesis method 7 - of, aminoheptanoic acid hydrochloride, belongs to the field: organic synthesis, and the reaction solution obtained by adding the cycloheptanone to the methanol solution, and adding concentrated HCl, to obtain, aminopimelic acid hydrochloride, is more suitable for large-scale production, by adding concentrated hydrochloric acid, reflux reaction 7 - to dichloromethane cooling crystallization. for producing the heptane lactam, in simple operation, of the present invention.
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Paragraph 0033-0042
(2020/03/16)
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- Transkarbams as transdermal permeation enhancers: Effects of ester position and ammonium carbamate formation
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Transkarbam 12, an ammonium carbamate formed by the reaction of dodecyl 6-aminohexanoate with carbon dioxide, is a highly active, broad-spectrum, nontoxic, and nonirritant transdermal permeation enhancer. It probably acts by a dual mechanism: a part of its activity is associated with the carbamic acid salt and/or its decomposition in the acidic stratum corneum. The ammonium ester thereby released is an active enhancer species as well, and its activity highly depends on the position of the ester group.
- Novotny, Michal,Hrabálek, Alexandr,Jan??ová, Barbora,Novotny, Jakub,Vávrová, Kate?ina
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scheme or table
p. 2726 - 2728
(2010/08/04)
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