- Red and blue emitting fluorescent probe for cyanide and hypochlorite ions: Biological sensing and environmental analysis
-
Excessive levels of hypochlorite and cyanide ions are considered as the major threats towards human health and environment. Therefore, many researchers make considerable effort to develop small molecules for the quick, accurate and easy detection of biolo
- Malkondu, Sait,Erdemir, Serkan,Karakurt, Serdar
-
-
Read Online
- A benzothiazole-based fluorescent probe for selective detection of H2S in living cells and mouse hippocampal tissues
-
This study reports a benzothiazole-based fluorescent probe EPS-HS for real-time detection of H2S. The probe is characterized in a large red-shift, good selectivity, high sensitivity and favorable biocompatibility. We measured the detection limi
- Liu, Yi,Ding, Yan,Huang, Jie,Zhang, Xiaofei,Fang, Tongyong,Zhang, Yuyun,Zheng, Xian,Yang, Xia
-
-
Read Online
- Synthesis and antibacterial activity of hydroxylated 2-arylbenzothiazole derivatives
-
N-acyliminium reagents formed in situ from benzothiazole and alkyl chloroformates react with hydroxyarenes in a Friedel-Crafts manner, providing access to 2-(hydroxyaryl)-benzothiazolines with antibacterial properties.
- Angelov, Plamen,Georgiev, Danail,Ivanov, Iliyan,Kirkova, Desislava,Statkova-Abeghe, Stela,Stremski, Yordan
-
-
Read Online
- A simple and sensitive fluorescent sensor platform for Al3+sensing in aqueous media and monitoring through combined PET and ESIPT mechanisms: Practical applications in drinking water and bio-imaging
-
In this study, a novel hydrazide-based compound, (E)-N′-(5-(benzo[d]thiazol-2-yl)-2-hydroxybenzylidene)furan-2-carbohydrazide (probe BOTH) was designed, characterized and prepared as a fluorogenic "turn-on"sensor for monitoring Al3+ in near-perfect aqueou
- Arslan, Fatma Nur,Aydin, Duygu,Gunay, Ibrahim Berk,Karuk Elmas, Sukriye Nihan,Sadi, Gokhan,Savran, Tahir,Yilmaz, Ibrahim
-
-
Read Online
- An efficient rapid synthesis of benzoxazoles and benzothiazoles using pma.Sio2 at room temperature under heterogeneous conditions
-
Treatment of 2-aminophenol (or 2-aminothiophenol) with aromatic aldehydes in the presence of phosphomolybdic acid on silica at room temperature affords the corresponding benzoxazoles (or benzothiazoles) in excellent yields (88-96%) under heterogeneous conditions. Benzoxazoles and benzothiazoles are formed in less than 10 min.
- Sudhakar, Chithaluri,Shekhar, Vanam,Shyamsunder, Manchi,Suryakumari, Adurthi,Manojkumar, Vala
-
p. 583 - 587
(2021/09/30)
-
- Ruthenium silicate (RS-1) zeolite: novel heterogeneous efficient catalyst for synthesis of 2-arylbenzothiazole derivatives
-
Abstract: Mesoporous silicate and transition metal (Ru+3) containing mesoporous silicate materials or ruthenium silicate Ru+3/Si+4 where synthesis by using hydrothermal process. Mesoporous ruthenium silicate (RS-1) and zeo
- Gadekar, Sachin P.,Lande, Machhindra K.
-
p. 1253 - 1267
(2021/01/06)
-
- Ionic liquid-immobilized hybrid nanomaterial: an efficient catalyst in the synthesis of benzimidazoles and benzothiazoles via anomeric-based oxidation
-
Abstract: In this study, a novel ionic liquid immobilized on silica-coated cobalt-ferrite magnetic nanoparticles. This novel hybrid nanostructure (CoFe2O4@SiO2@PAF-IL) was characterized by various microscopic and spectroscopic techniques including Fourier transformation infrared spectroscopy (FT–IR), X-ray powder diffraction (XRD), field emission scanning electron microscopy (SEM), the electron-dispersive X-ray spectroscopy (EDS), vibrating sample magnetometer (VSM), and thermogravimetric analysis (TGA/DTG). The catalytic activity of prepared nanomaterial was considered in the synthesis of the benzothiazole and benzimidazole derivatives. This method has several advantages such as good to excellent yields, short reaction times, solvent-free and environmentally-benign conditions, and simple work-up. Besides, nanocatalyst can be easily separated from the reaction mixture with the external magnetic field and reused several times without any loss of its catalytic activity. Graphic abstract: [Figure not available: see fulltext.].
- Bodaghifard, Mohammad Ali,Shafi, Saeideh
-
p. 677 - 687
(2020/09/18)
-
- Pentafluorophenylammonium Triflate: A Mild, Efficient and Reusable Catalyst for the Synthesis of 2-Arylbenzothiazole and 2-Arylbenzothiazoline Derivatives in a Green Chemical Approach
-
In this work, one pot, simple and environmentally benign effective synthesis of 2-substituted benzothiazole and benzothiazoline derivatives are described in presence of PFPAT (pentafluorophenylammonium triflate) catalyst in water successfully. A series of benzothiazole derivative were synthesized by the reaction between 2-aminothiophenol and various aldehydes in good yields. Recyclability of the catalyst is observed for four times without loss of its activity in aqueous medium.
- Datta, Arup
-
-
- 2-Aryl benzazole derived new class of anti-tubercular compounds: Endowed to eradicate mycobacterium tuberculosis in replicating and non-replicating forms
-
The high mortality rate and the increasing prevalence of Mtb resistance are the major concerns for the Tuberculosis (TB) treatment in this century. To counteract the prevalence of Mtb resistance, we have synthesized 2-aryl benzazole based dual targeted molecules. Compound 9m and 9n were found to be equally active against replicating and non-replicating form of Mtb (MIC(MABA) 1.98 and 1.66 μg/ml; MIC(LORA) 2.06 and 1.59 μg/ml respectively). They arrested the cell division (replicating Mtb) by inhibiting the GTPase activity of FtsZ with IC50 values 45 and 64 μM respectively. They were also capable of kill Mtb in non-replicating form by inhibiting the biosynthesis of menaquinone which was substantiated by the MenG inhibition (IC50 = 11.62 and 7.49 μM respectively) followed by the Vit-K2 rescue study and ATP production assay.
- Datta, Dhrubajyoti,Debnath, Joy,Franzblau, Scott G.,Ghosh, Kalyan Sundar,Hari, Natarajan,Ma, Rui,Rana, Shiwani,Velappan, Anand Babu
-
-
- Three-Component, Interrupted Radical Heck/Allylic Substitution Cascade Involving Unactivated Alkyl Bromides
-
Developing efficient and selective strategies to approach complex architectures containing (multi)stereogenic centers has been a long-standing synthetic challenge in both academia and industry. Catalytic cascade reactions represent a powerful means of rapidly leveraging molecular complexity from simple feedstocks. Unfortunately, carrying out cascade Heck-type reactions involving unactivated (tertiary) alkyl halides remains an unmet challenge owing to unavoidable β-hydride elimination. Herein, we show that a modular, practical, and general palladium-catalyzed, radical three-component coupling can indeed overcome the aforementioned limitations through an interrupted Heck/allylic substitution sequence mediated by visible light. Selective 1,4-difunctionalization of unactivated 1,3-dienes, such as butadiene, has been achieved by employing different commercially available nitrogen-, oxygen-, sulfur-, or carbon-based nucleophiles and unactivated alkyl bromides (>130 examples, mostly >95:5 E/Z, >20:1 rr). Sequential C(sp3)-C(sp3) and C-X (N, O, S) bonds have been constructed efficiently with a broad scope and high functional group tolerance. The flexibility and versatility of the strategy have been illustrated in a gram-scale reaction and streamlined syntheses of complex ether, sulfone, and tertiary amine products, some of which would be difficult to access via currently established methods.
- Bellotti, Peter,Glorius, Frank,Heidrich, Bastian,Huang, Huan-Ming,Pflüger, Philipp M.,Schwarz, J. Luca
-
supporting information
p. 10173 - 10183
(2020/06/27)
-
- Preparation method of 2-aryl benzothiazole compound
-
The invention discloses a preparation method of a 2-arylbenzothiazole compound, which comprises the following steps: adding a reaction substrate 2-aminothiophenol and ketonic acid(or aldehyde) into adeep eutectic solvent, magnetically stirring in an oil bath pot at 60-90 DEG C, and carrying out after-treatment after the reaction is finished to obtain the 2-arylbenzothiazole compound, wherein a deep eutectic solvent is a reaction solvent, and other catalysts are not needed. The method is simple to operate, mild in reaction condition, efficient in reaction, high in atom economy, few in byproducts and green and environment-friendly in reaction process, and has popularization and application values.
- -
-
Paragraph 0116; 0119-0120
(2020/05/09)
-
- Aerobic oxidative synthesis of quinazolinones and benzothiazoles in the presence of laccase/DDQ as a bioinspired cooperative catalytic system under mild conditions
-
The current study applied laccase/DDQ as a bioinspired cooperative catalytic system for the synthesis of quinazolinones (80-95% yield) and benzothiazoles (65-98% yield) using air or O2 as ideal oxidants in aqueous media at ambient temperature. The aerobic oxidative cyclization reactions occur in two steps: (i) chemical cyclization; (ii) chemoenzymatic oxidation. These methods are more environment-friendly, efficient, simple and practical than other reported methods due to the use of O2 as an oxidant, laccase as an eco-friendly biocatalyst, aqueous media as the solvent and free from any toxic transition metal and halide catalysts. Therefore, these methods can be applied in pharmaceutical and other sensitive synthetic procedures.
- Abdelrasoul, Amira,Ghorashi, Nadia,Moradi, Reza,Rostami, Amin,Shokri, Zahra
-
p. 14254 - 14261
(2020/04/23)
-
- Design, synthesis and evaluation of benzothiazole derivatives as multifunctional agents
-
Oxidative stress is the product or aetiology of various multifactorial diseases; on the other hand, the development of multifunctional compounds is a recognized strategy for the control of complex diseases. To this end, a series of benzothiazole derivatives was synthesized and evaluated for their multifunctional effectiveness as antioxidant, sunscreen (filter), antifungal and antiproliferative agents. Compounds were easily synthesized via condensation reaction between 2-aminothiophenols and different benzaldehydes. SAR study, particularly in position 2 and 6 of benzothiazoles, led to the identification of 4g and 4k as very interesting potential compounds for the design of multifunctional drugs. In particular, compound 4g is the best blocker of hERG potassium channels expressed in HEK 293 cells exhibiting 60.32percent inhibition with IC50 = 4.79 μM.
- Andreotti, Elisa,Baldisserotto, Anna,Balzarini, Jan,Buzzi, Raissa,Dissette, Valeria,Djuidje, Ernestine Nicaise,Liekens, Sandra,Manfredini, Stefano,Sciabica, Sabrina,Serra, Elena,Vertuani, Silvia
-
-
- Oxidative NHC catalysis for base-free synthesis of benzoxazinones and benzoazoles by thermal activated NHCs precursor ionic liquid catalyst using air as oxidant
-
A reusable thermal activated NHC precursor ionic liquid catalyst ([BMIm]2[WO4]) has been prepared and developed for the synthesis of nitrogen-containing heterocycles such as benzoxazinones and benzoazoles through imines activation. [BMIm]2[WO4] exhibited the good activity for the base-free condensation and oxidative NHC catalysis tandem under air atmosphere. The catalyst can be recovered and reused for at least five runs in gram scale synthesis without any decrease in catalytic activity. Furthermore, the control experiments demonstrated that the reaction involved formation of aromatic aldimines, NHC-catalyzed oxidative formation of imidoyl azoliums and intramolecular cyclization to generate the product.
- Guan, Jiali,Liu, Wei,Liu, Yuchen,Song, Zhibin,Tao, Duan-Jian,Yan, Jieying,Yuan, Jian-Jun,Zhou, Youkang
-
-
- SOLID FORMS OF A PROMOTER OF SPINOGENESIS
-
Provided herein are crystalline forms of 2-(2-(2-(2-(4-(benzo[d]thiazol-2-yl)phenoxy)ethoxy)ethoxy)ethoxy)ethan-l-ol (Compound I): Also provided are processes of manufacture and methods of using the crystalline forms.
- -
-
Page/Page column 49-50
(2020/08/22)
-
- Quantitative structure activity relationship studies of novel hydrazone derivatives as α-amylase inhibitors with index of ideality of correlation
-
The present manuscript describes the synthesis, α-amylase inhibition, in silico studies and in-depth quantitative structure–activity relationship (QSAR) of a library of aroyl hydrazones based on benzothiazole skeleton. All the compounds of the developed l
- Duhan, Meenakshi,Sindhu, Jayant,Kumar, Parvin,Devi, Meena,Singh, Rahul,Kumar, Ramesh,Lal, Sohan,Kumar, Ashwani,Kumar, Sudhir,Hussain, Khalid
-
-
- Quinoline derivative as well as preparation method and application thereof (by machine translation)
-
The invention provides a quinoline derivative and a composition containing the same. The invention also provides a method for preparing the derivative and application of the derivative and the composition to kill pests. (by machine translation)
- -
-
Paragraph 0440-0444
(2019/11/28)
-
- Method for synthesizing benzothiazole by microwave radiation of benzothioamide compound in aqueous phase
-
The invention discloses a method for synthesizing benzothiazole by microwave radiation of a benzothioamide compound in an aqueous phase. The method includes the steps: adding the benzothioamide compound into the aqueous phase under microwave conditions; performing cyclization under alkaline conditions to generate the benzothiazole. The method for preparing the benzothiazole is environmentally friendly, simple and convenient in operation, safe, cheap and efficient. Compared with the prior art, the method is applicable to a lot of functional groups, high in yield, few in by-products, simple in operation, safe, low in cost and environmentally friendly.
- -
-
Paragraph 0013; 0050
(2019/02/13)
-
- Method used for rapid preparation of benzo-heterocycle compound with physical grinding under solvent-free room temperature conditions
-
The invention discloses a method used for rapid preparation of benzo-heterocycle compound with physical grinding under solvent-free room temperature conditions. According to the method, glacial aceticacid is taken as a catalyst; at solvent-free room temperature conditions, physical grinding is adopted, reaction of 2-substituted arylamines (2-mercapto arylamine, 2-aminophenol, and o-phenylenediamine) and aromatic aldehydes is carried out using physical grinding. The method is friendly to the environment, is simple in operation, is safe, is low in cost, and is high in efficiency. Compared withthe prior art, the advantages are that: the method is suitable for a large amount of functional groups, yield is high, less by-product is generated, operation is simple, the method is safe, cost is low, and the method is friendly to the environment.
- -
-
Paragraph 0062; 0127
(2019/01/21)
-
- A novel ternary GO@SiO2-HPW nanocomposite as an efficient heterogeneous catalyst for the synthesis of benzazoles in aqueous media
-
A new solid acid catalyst, consisting of 12-phosphotungstic heteropoly acid (HPW) supported on graphene oxide/silica nanocomposite (GO@SiO2), has been developed via immobilizing HPW onto an amine-functionalized GO/SiO2 surface through coordination interaction (GO@SiO2-HPW). The GO@SiO2-HPW nanocomposite was characterized by Fourier transform infrared (FT-IR) spectroscopy, thermogravimetric analysis (TGA), scanning electron microscopy (SEM), and powder X-ray diffraction (XRD). The prepared nanocomposite could be dispersed homogeneously in water and further used as a heterogeneous, reusable, and efficient catalyst for the synthesis of benzimidazoles and benzothiazoles by the reaction of 1,2-phenelynediamine or 2-aminothiophenol with different aldehydes.
- Habibzadeh, Setareh,Firouzzadeh Pasha, Ghasem,Tajbakhsh, Mahmood,Amiri Andi, Nasim,Alaee, Ehsan
-
p. 934 - 944
(2019/06/13)
-
- Cholesterol linked benzothiazole: A versatile gelator for detection of picric acid and metal ions such as Ag+, Hg2+, Fe3+ and Al3+ under different conditions
-
Cholesterol-appended benzothiazole 1 has been designed and synthesized. Compound 1 exhibits gelation in different solvents. The benzothiazole and cholesteryl motifs play a pivotal role in aggregation in organic solvents involving π-stacking and hydrophobic interactions, respectively. As an application, the nitrobenzene gel with good rheological properties has been noted to be useful in molecular recognition studies of multiple analytes ranging from neutral to ionic in nature. It selectively recognizes picric acid (PA) over a series of nitroaromatics by exhibiting a gel-to-sol phase transition with a distinguishable color change from pale yellow to deep yellow. On the other hand, the nitrobenzene gel shows selective recognition potential for Ag+ and Hg2+ ions through a gel-to-sol phase transition and the cations are distinguished by F-. The gelator 1 also reveals a measurable selective interaction with picric acid over a series of nitroaromatics in CH3CN containing 1% CHCl3. In CH3CN containing 1% CHCl3, compound 1 further shows affinity towards Fe3+, Al3+ and Hg2+ with distinctive features.
- Mondal, Subhendu,Raza, Rameez,Ghosh, Kumaresh
-
p. 10509 - 10516
(2019/07/08)
-
- 2-Arylation/alkylation of benzothiazoles using superparamagneticgraphene oxide-Fe3O4 hybrid material as a heterogeneous catalystwith diisopropyl azodicarboxylate (DIAD) as an oxidant
-
In this report, we introduced Graphene oxide-iron oxide (GO-Fe3O4) nanocomposites as a heterogeneous catalyst for arylation/alkylation of benzothiazoles with aldehydes and benzylic alcohols in the presence of diisopropyl azodicarboxylate (DIAD) as an oxidant which exclusively produced 2-aryl (alkyl)-1H–benzothizoles in moderate to excellent yields. The absence of precious metals and toxic solvent, easy product isolation, and recyclability of the GO-Fe3O4 with no loss of activity are notable advantages of this method.
- Khalili, Dariush,Etemadi-Davan, Elham,Banazadeh, Ali Reza
-
-
- MIL-101(Fe) hexagonal microspindle as a highly efficient, reusable and versatile catalyst for benzo-fused heterocyclic nucleus synthesis
-
A highly reusable, efficient and versatile MIL-101(Fe) catalyst was prepared and characterized using various techniques including Fourier transform infrared spectroscopy, X-ray diffraction, field emission scanning electron microscopy and energy-dispersive X-ray spectroscopy. This heterogeneous catalyst demonstrated a promising activity for condensation/cyclization reactions of various aryl aldehydes with 1,2-phenylenediamine or 2-aminothiophenol. The corresponding benzo-fused heterocyclic products were generated in good to excellent yields under mild conditions in the presence of the catalyst. In addition, the catalyst can be easily separated and reused in eight consecutive runs with consistent catalytic activity.
- Karimian, Ramin,Davarpanah, Seyed Javad
-
-
- Solid Acid Supported on Magnetic Nanoparticles as a Highly Efficient and Retrievable Catalyst for the Synthesis 2-Substituted Benzothiazoles
-
The use of a recyclable heterogeneous nanomagnetic solid acid catalyst, [Fe3O4@SiO2@(CH2)3NPC–SO3H]Cl, in a simple and highly efficient synthesis of benzothiazole derivatives by the reactio
- Gorjizadeh,Sayyahi
-
p. 1899 - 1903
(2018/11/24)
-
- Synthesis and insecticidal activity of novel benzothiazole derivatives containing the coumarin moiety
-
A series of novel benzothiazole derivatives containing a coumarin moiety was designed and synthesized. Their structures were characterized in detail via 1H NMR, 13C NMR, HRMS spectra and single-crystal X-ray diffraction analysis. The bioassay results indicated that some compounds showed encouraging insecticidal activity against Plutella xylostella and Aphis fabae at 400 mg/L. The preliminary structure-activity relationships were also discussed.
- Si, Wei-Jie,Chen, Min,Wang, Xue-Lun,Wang, Meng-Qi,Jiao, Jian,Fu, Xin-Can,Yang, Chun-Long
-
-
- Iridium complex with double-emission properties, method for preparing iridium complex and application thereof
-
The invention provides an iridium complex with double-emission properties, a method for preparing the iridium complex and application thereof. A structural formula of the iridium complex is shown. Theiridium complex comprises a metal iridium center, a neu
- -
-
Paragraph 0034; 0035; 0036
(2018/05/16)
-
- Synthesis of 2 - substituted benzothiazole derivatives
-
The invention discloses a method of synthesizing a 2-substituted benzothiazole-type derivative, wherein the method includes a step of synthesizing the 2-substituted benzothiazole-type derivative with an aldehyde and a disulphide as raw materials under a combined effect of at least one from NaHCO3 and AcOH with a metal sulfide. The particular reaction is represented as follows, wherein the R comprises one or more from a hydrogen atom, a C1-C4 alkyl, a fluorine atom, a chlorine atom, a bromine atom, an amino group, a cyan group and a nitryl group; the R' substituent group comprises at least one from a C1-C6 alkyl, a furan group, a thienyl group, a pyrryl group, a pridyl group and a substituted phenyl group. The method employs the raw material being stable and easy to obtain, and can quickly and conveniently synthesize the 2-substituted benzothiazole-type derivative at a high production yield.
- -
-
Paragraph 0071-0075
(2017/07/23)
-
- Efficient synthesis of benzothiazole derivatives by reaction of bis(2-aminophenyl) disulfides with aldehydes mediated by NaSH under microwave irradiation
-
2-Substituted benzothiazoles were synthesized through condensation of bis(2-aminophenyl) disulfides with arylaldehydes catalyzed by inexpensive NaSH in PEG-300 and assisted by low energy microwave irradiation(25?W). Various 2-substitutedbenzothiazoles were obtained in moderate to high yields after simple post-reaction processing including adding distilled water, filtrating, and drying. Moreover, it was found that the S-S bond of the disulfide was reduced by NaSH and also by the intermediate benzothiazoline.
- Liu, Lei,Zhang, Fa,Wang, Hongliang,Zhu, Ning,Liu, Bo,Hong, Hailong,Han, Limin
-
p. 464 - 468
(2017/04/03)
-
- Triethylene glycol-modified iridium(III) complexes for fluorescence imaging of: Schistosoma japonicum
-
Schistosomiasis, an infectious disease caused by the Schistosoma parasitic worm, presents a serious public health issue. To date, investigation of anti-Schistosomiasis drug mechanisms through fluorescence imaging remains challenging due to the lack of appropriate dyes as fluorescent probes. Phosphorescent Ir(iii) complexes have been attracting substantial attention among various classes of fluorophores given their excellent photophysical properties. Herein, four phosphorescent Ir(iii) complexes were synthesized, two of which contained a triethylene glycol (TEG) hydrophilic group. The phosphorescent emission range of the four complexes lay between 500 and 750 nm, and their quantum yields ranged from 0.031 to 0.146. Furthermore, under the experimental concentration conditions, the TEG-modified complexes had low cytotoxicity. Cell fluorescence labeling experiments indicated that the TEG-modified complexes had good membrane permeability. Finally, the TEG-modified complexes showed remarkable labeling effects in adult Schistosoma fluorescence imaging. Thus, TEG-modified Ir(iii) complexes could be used as a new class of bilharzial fluorescent probes.
- Wu, Yongquan,Zeng, Guanjie,Lvyue, Nannan,Wu, Weihua,Jiang, Tianyu,Wu, Rongle,Guo, Wei,Li, Xun,Fan, Xiaolin
-
p. 4973 - 4980
(2017/07/11)
-
- A phosphorescence iridium complex synthesis and its used for cercarian fluorescence-labeled
-
The invention belongs to the field of photobiology labeling for preventing and treating parasitic diseases, and relates to synthesis of a phosphorescent iridium complex and the purpose of the phosphorescent iridium complex for the fluorescence labeling of
- -
-
Paragraph 0038
(2018/01/11)
-
- Chromium(III)-salen complex nanoparticles on AlPO4: as an efficient heterogeneous and reusable nanocatalyst for mild synthesis of highly functionalized piperidines, 2-arylbenzimidazoles, and 2-arylbenzothiazoles
-
Abstract: A simple, convenient, and highly efficient multicomponent one-pot synthesis of highly functionalized piperidines has been developed via tandem reactions of β-keto esters, aromatic aldehydes, and various amines in ethanol at room temperature using catalytic amount (10?mol%) of a chromium(III)-salen complex nanoparticles supported on AlPO4. The heterogeneous catalyst exhibited excellent activity and reusability (up to 8 times) in the synthesis of highly functionalized piperidines. Also, synthesis of 2-arylbenzimidazoles and 2-arylbenzothiazoles have been efficiently developed under mild condition from o-phenylenediamines or 2-aminothiophenol with aryl aldehydes via one-step process using catalytic amount (2.0?mol%) of nanocatalyst in air atmosphere as a green oxidant. The heterogeneous catalyst was characterized by scanning electron microscopy, atomic force microscopy, inductively coupled plasma spectrometry, thermogravimetry for analysis of nitrogen adsorption, and FT-IR spectroscopy. Graphical Abstract: [Figure not available: see fulltext.].
- Sharghi, Hashem,Aberi, Mahdi,Doroodmand, Mohammad Mahdi,Shiri, Pezhman
-
p. 1557 - 1573
(2017/06/06)
-
- A green approach to the synthesis of a nano catalyst and the role of basicity, calcination, catalytic activity and aging in the green synthesis of 2-aryl bezimidazoles, benzothiazoles and benzoxazoles
-
A green synthesis of hydrotalcite (a double layered catalyst) by a grinding method using Al/Mg molar ratios of 1.0-3.0 at room temperature is described. The prepared double layered catalyst (hydrotalcite) has been characterized by TG, FT-IR, SEM, XRD and Hammett titration methods. Different factors such as the effect of molar ratios, catalyst loading, reaction time, aging time, and basicity have been investigated for the facile, efficient and green synthesis of 2-arylbenzimidazoles, benzothiazoles and benzoxazoles under solvent free conditions. The influence of catalyst loading on reactivity was studied and a catalyst loading of 20 mg was found to be optimal, giving the best yield with minimum time as compared to other catalysts. The present methodology reports, herein, a rapid and cost effective synthesis of hydrotalcite and its versatile applications in the synthesis of 2-arylbenzimidazoles, benzothiazoles and benzoxazoles.
- Sahu, Pramod K.
-
p. 42000 - 42012
(2017/09/12)
-
- Green and Highly Efficient Synthesis of Mono- and Bis-Benzothiazoles in the Presence of Fe(SD)3 under Ultrasound Irradiation
-
A convenient, practical, green, and environmentally friendly method was developed for the synthesis of benzothiazoles from 2-aminothiophenol and various aldehydes. Bis-benzothiazoles were synthesized in high yield under mild reaction conditions. Products
- Pirbasti, Fateme Ghanbari,Mahmoodi, Nosrat Ollah
-
-
- Synthesis of some benzothiazoles by developing a new protocol using urea nitrate as a catalyst and their antimicrobial activities
-
The present communication demonstrates the development of urea nitrate as an effective and efficient catalyst for the synthesis of some 2-substituted benzothiazoles. Instant progress of reaction at room temperature under solvent-free condition, very high catalytic activity, inexpensive, clean reaction profile, operational simplicity, large-scale synthesis and appreciable yields are the main advantages of this protocol. These synthesized benzothiazoles have been evaluated for their antibacterial and antifungal activities against Gram-positive bacterium (Bacillus subtilis MTCC 121); two Gram-negative bacteria (Escherichia coli MTCC 1652 and Pseudomonas aeruginosa MTCC 741) and two fungi (Candida albicans MTCC 3017 and Saccharomyces cerevisiae MTCC 170). Compound 3n was found the most active against all the tested microbes.
- Kumar, Parvin,Bhatia, Rimpy,Khanna, Radhika,Dalal, Aarti,Kumar, Dinesh,Surain, Parveen,Kamboj, Ramesh C.
-
p. 585 - 596
(2017/10/05)
-
- Method for realizing green synthesis of 2-substituted benzothiazole derivatives
-
The invention provides a method for realizing green synthesis of 2-substituted benzothiazole derivatives. The method comprises the following steps of: contacting aldehyde, o-amido aroma disulphide and metal sulfide by taking water as a solvent in the present of CO2, so as to obtain 2-substituted benzothiazole derivatives. Compared with the prior art, the method has the characteristics that o-amido aroma disulphide and multiple types of aldehyde react under the effects of water and CO2, so that the 2-substituted benzothiazole derivatives are rapidly and efficiently synthetized, and the used raw materials are easily obtained and low in cost; the synthesis method has the advantages of simplicity and convenience in operation, short steps, high yield, easiness for product purification, environmental friendliness and the like.
- -
-
Paragraph 0076; 0077; 0078; 0079; 0080; 0081; 0082-83
(2016/10/10)
-
- Novel Cu(0)-Fe3O4@SiO2/NH2cel as an Efficient and Sustainable Magnetic Catalyst for the Synthesis of 1,4-Disubstituted-1,2,3-triazoles and 2-Substituted-Benzothiazoles via One-Pot Strategy in Aqueous Media
-
A novel, air stable, water dispersible and efficient magnetic catalyst based on copper nanoparticles onto ethylene diamine functionalized inorganic/organic composite [Cu(0)-Fe3O4@SiO2/NH2cel] has been prepared. Functionalization of inorganic/organic composite by ethylene diamine imparts desirable chemical functionality and enables the generation of active sites for the immobilization of Cu(0) nanoparticles. The novel catalyst system has been well characterized by various techniques like FTIR, TGA, XRD, SEM, HRTEM, EDX, ICP-AES, UV-Vis and VSM. Further, Cu(0)-Fe3O4@SiO2/NH2cel opens up a new avenue to introduce a very useful and efficient catalytic system for the one-pot synthesis of 1,4-disubstituted-1,2,3-triazoles via 1,3-dipolar cycloaddition of terminal acetylenes to azides, generated in situ from anilines in water at room temperature, and one-pot three component reaction of 2-iodoaniline, aldehyde and thiourea as sulphur source for the synthesis of 2-substituted-benzothiazole derivatives in water. The novel heterogeneous magnetic catalyst offers recyclability without significant deterioration in catalytic activity and can be easily recovered using an external magnet, thus making it eco-friendly and economical to perform the desired transformations.
- Bhardwaj, Madhvi,Jamwal, Babita,Paul, Satya
-
p. 629 - 644
(2016/02/26)
-
- Microwave assisted aqueous phase synthesis of benzothiazoles and benzimidazoles in the presence of Ag2O
-
A simple and high yielding method for synthesized benzothiazoles and benzimidazole in water under micro wave irradiation by the reaction of 2-amino thiophenol and o-phenylenediamine with various aromatic aldehydes in the presence of Ag2O. Agsu
- Sakram,Rambabu,Ashok,Sonyanaik,Ravi
-
p. 2737 - 2743
(2017/03/22)
-
- Fe3O4@SiO2@polyionene/Br3- core-shell-shell magnetic nanoparticles: A novel catalyst for the synthesis of imidazole derivatives under solvent-free conditions
-
New Fe3O4@SiO2@polyionene/Br3- core-shell-shell magnetite nanoparticles were prepared using a co-precipitation method and were used in the syntheses of imidazole derivatives under solvent-free conditions. The polyionene was easily prepared by reacting DABCO and 1,4-dibromo butane in DMF/methanol. It was then added to the previously formed layers and magnetic core-shell nanoparticles (P-MNPs) were functionalized. All the resultant nanoparticles were characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), infrared spectroscopy (FTIR), X-ray diffraction (XRD), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), and vibrating sample magnetometry (VSM). The catalyst was readily recovered by simple magnetic decantation and can be recycled several times with no significant loss of catalytic activity.
- Dezfoolinezhad, Elham,Ghodrati, Keivan,Badri, Rashid
-
p. 4575 - 4587
(2016/06/09)
-
- Epichlorohydrin cross-linked β -cyclodextrin: An environmental method for the synthesis of 2-arylbenzothiazoles derivatives in water
-
In the present study, we report an environmentally benign synthesis of 2-arylbenzothiazoles derivatives from o-aminothiophenol and aldehydes in aqueous medium using β-cyclodextrin polymer as a catalyst and air as an oxidant. The polymer showed excellent c
- El-Remaily, Mahmoud Abd El Aleem Ali Ali,Soliman, Ahmed M. M.
-
-
- Method for catalytic synthesis of 2-substituted benzothiazole compound by utilizing Yb/MCM-41 molecular sieve-based catalyst
-
The invention relates to a method for the catalytic synthesis of a 2-substituted benzothiazole compound by utilizing a Yb/MCM-41 molecular sieve-based catalyst. The method comprises the steps of (a) subjecting 2-amino thiophenol, an aldehyde compound and
- -
-
Paragraph 0095; 0096; 0097; 0098; 0099
(2016/10/17)
-
- Role of graphene oxide as a heterogeneous acid catalyst and benign oxidant for synthesis of benzimidazoles and benzothiazoles
-
We report the synthesis of benzothiazoles and benzimidazoles using graphene oxide as an effective catalyst with good yields and easy recyclability. Graphene oxide plays the dual role of a metal-free acid catalyst and an oxidizing agent. The mechanism of a
- Dhopte, Kiran B.,Zambare, Rahul S.,Patwardhan, Anand V.,Nemade, Parag R.
-
p. 8164 - 8172
(2016/02/05)
-
- Antidiabetic potential and enzyme kinetics of benzothiazole derivatives and their non-bonded interactions with α-glucosidase and α-amylase
-
Benzothiazole derivatives were synthesized and their antidiabetic potential evaluated using α-glucosidase, α-amylase, non-enzymatic glycosylation of hemoglobin and advanced glycation end product inhibition assays. Compound 3l showed low IC50 va
- Puranik, Ninad V.,Puntambekar, Hemalata M.,Srivastava, Pratibha
-
p. 805 - 816
(2016/03/08)
-
- The immunomodulation potential of the synthetic derivatives of benzothiazoles: Implications in immune system disorders through in vitro and in silico studies
-
Benzothiazole and its natural or synthetic derivatives have been used as precursors for several pharmacological agents for neuroprotective, anti-bacterial, and anti-allergic activities. The objecctive of the present study was to evaluate effects of benzot
- Khan, Khalid Mohammed,Mesaik, Mohammad A.,Abdalla, Omer M.,Rahim, Fazal,Soomro, Samreen,Halim, Sobia A.,Mustafa, Ghulam,Ambreen, Nida,Khalid, Ahmad Shukralla,Taha, Muhammad,Perveen, Shahnaz,Alam, Muhammad Tanveer,Hameed, Abdul,Ul-Haq, Zaheer,Ullah, Hayat,Rehman, Zia Ur,Siddiqui, Rafat Ali,Voelter, Wolfgang
-
-
- 3-(benzo[d]thiazol-2-YL)phenol and 4-(benzo[d]thiazol-2-YL)phenol: Crystal Structure Determination, DFT Calculations and Visualizing Intermolecular Interactions Using Hirshfeld Surface Analysis
-
This article describes the synthesis and X-ray crystal structure analysis of 3-(benzo[d]thiazol-2-yl) phenol (I) and 4-(benzo[d]thiazol-2-yl)phenol (II), crystallized in centrosymmetric triclinic and orthorhombic space groups respectively. The packing in
- Mudsainiyan,Jassal
-
p. 120 - 134
(2016/07/06)
-
- Luminescent ion pairs with tunable emission colors for light-emitting devices and electrochromic switches
-
Most recently, stimuli-responsive luminescent materials have attracted increasing interest because they can exhibit tunable emissive properties which are sensitive to external physical stimuli, such as light, temperature, force, and electric field. Among these stimuli, electric field is an important external stimulus. However, examples of electrochromic luminescent materials that exhibit emission color change induced by an electric field are limited. Herein, we have proposed a new strategy to develop electrochromic luminescent materials based on luminescent ion pairs. Six tunable emissive ion pairs (IP1-IP6) based on iridium(iii) complexes have been designed and synthesized. The emission spectra of ion pairs (IPs) show concentration dependence and the energy transfer process is very efficient between positive and negative ions. Interestingly, IP6 displayed white emission at a certain concentration in solution or solid state. Thus, in this contribution, UV-chip (365 nm) excited light-emitting diodes showing orange, light yellow and white emission colors were successfully fabricated. Furthermore, IPs displayed tunable and reversible electrochromic luminescence. For example, upon applying a voltage of 3 V onto the electrodes, the emission color of the solution of IP1 near the anode or cathode changed from yellow to red or green, respectively. Color tunable electrochromic luminescence has also been realized by using other IPs. Finally, a solid-film electrochromic switch device with a sandwiched structure using IP1 has been fabricated successfully, which exhibited fast and reversible emission color change.
- Guo, Song,Huang, Tianci,Liu, Shujuan,Zhang, Kenneth Yin,Yang, Huiran,Han, Jianmei,Zhao, Qiang,Huang, Wei
-
p. 348 - 360
(2016/12/30)
-
- Green, efficient and large-scale synthesis of benzimidazoles, benzoxazoles and benzothiazoles derivatives using ligand-free cobalt-nanoparticles: As potential anti-estrogen breast cancer agents, and study of their interactions with estrogen receptor by mo
-
A facile and high yielding method for the synthesis of 2-aryl benzoxazoles, benzimidazole and benzothiazoles is reported employing cobalt oxide nanoparticles. The cobalt oxide nanoparticles were used as a convenient, green, easy available and highly effic
- Hajipour, Abdol R.,Khorsandi, Zahra,Mortazavi, Maryam,Farrokhpour, Hossein
-
p. 107822 - 107828
(2016/01/09)
-
- Piperazinylpyrimidine modified MCM-41 for the ecofriendly synthesis of benzothiazoles by the simple cleavage of disulfide in the presence of molecular O2
-
This is the first report of a sustainable and toxic metal free synthesis of benzothiazoles by the cleavage of ortho-aminothiophenol disulfide using a silica-supported heterogeneous catalyst in water in the presence of molecular O2 as a stoichiometric oxidant. For this purpose a new heterogeneous catalyst (MCM-PP) was synthesized by post synthesis grafting of 2-(piperazin-1-yl)pyrimidine functionalized organosilane onto MCM-41 mesoporous silica and it was characterized by BET surface area analysis, SAXRD, UHR TEM, CHN analysis, 13C CP MAS and 29Si MAS NMR. The reaction requires two different catalytic functions, i.e., an acidic one which is given by MCM-41 and a basic one, given by the organic base moiety anchored to the MCM-41. The greenness of the process was assured as water was exploited as the reaction medium and O2 from air as the stoichiometric oxidant. Furthermore the leaching of the active site can also be avoided as the organic moieties are covalently attached to the inorganic support. Standard leaching experiments proved that the reaction was heterogeneous with this recyclable catalyst.
- Ray, Suman,Das, Paramita,Banerjee, Biplab,Bhaumik, Asim,Mukhopadhyay, Chhanda
-
p. 72745 - 72754
(2015/09/15)
-
- Novel synthesis of benzothiazole by self-redox tandem reaction of disulfide with aldehyde
-
A novel methodology for the preparation of benzothiazole derivatives via the reaction of ortho-anilino disulfides with aryl and heteroaryl aldehydes catalyzed by Na2S·9H2O has been developed. The reaction mechanism was investigated by LC-MS and 1H NMR. The disulfide was cleaved firstly by the interchange reaction of the disulfide and metal sulfide, and the resulting thiol reacted in situ with the aldehyde to form the corresponding benzothiazoline. Subsequently, the intermediate benzothiazoline reduced the disulfide to thiol and it was oxidized to benzothiazole. The excess benzothiazoline was oxidized by air and both halves of the disulfide were ultimately converted to the desired benzothiazole.
- Liu, Bo,Zhu, Ning,Hong, Hailong,Han, Limin
-
p. 9287 - 9292
(2015/11/27)
-
- Graphene oxide as a heterogeneous reagent promoted synthesis of 2-substituted 1,3-benzazoles in water
-
An efficient chemical method for the synthesis of benzimidazoles, benzothiazoles, and benzoxazoles has been developed through the condensation of various aldehydes with o-phenylenediamine, o-aminothiophenol, and o-aminophenol using graphene oxide (GO) as an oxidant in water. These benzazoles are also prepared through a one-pot oxidation/condensation tandem process by reacting alcohols with 2-amino-(thio)phenol/aniline in the presence of GO in poly(ethylene glycol) as a safe media. Moreover, this carbonaceous material could be readily separated using a simple filtration.
- Khalili, Dariush,Banazadeh, Ali Reza
-
p. 1693 - 1706
(2016/01/26)
-
- Samarium(III) triflate: A new catalyst for facile synthesis of benzothiazoles and benzoxazoles from carboxylic acids in aqueous media
-
A facile synthetic method for benzothiazoles and benzoxazoles comprising the reaction of corresponding 2-aminothiophenol and 2-aminophenol with various substituted aromatic carboxylic acids using Samarium(III) triflate as a catalyst has been described. The advantages of the method are short reaction times and aqueous reaction media and easy work-up. The catalysts can be recovered for the subsequent reactions and reused without any appreciable loss of efficiency.
- Gorepatil, Pratapsinha B.,Mane, Yogesh D.,Gorepatil, Amarsinha B.,Gaikwad, Mahadev V.,Ingle, Vilas S.
-
p. 8355 - 8362
(2015/10/20)
-