- Experimental and theoretical studies of azo derivatives in terms of different donors, acceptors and position isomerism: Synthesis, characterization and a combined electronic absorption, electrochemical and DFT study
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Eight azo derivatives with two donor groups- diphenylamine and N,N-dimethylphenyl, and four acceptor groups - 3-nitrophenyl, 4-nitrophenyl, 4-phenylcarboxylic acid, and 3-phenylcarboxylic acid, were synthesized and characterized using 1H-NMR an
- Mohan A, Keerthi,Purushothaman, Aiswarya,Janardanan, Deepa,Haridas, Karickal R.
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- Incorporation of a FRET pair within a phosphonate diester
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Cell-cleavable protecting groups are an effective tactic for construction of biological probes because such compounds can improve problems with instability, solubility, and cellular uptake. Incorporation of fluorescent groups in the protecting groups may afford useful probes of cellular functions, especially for payloads containing phosphonates that would be highly charged if not protected, but little is known about the steric or electronic factors that impede release of the payload. In this report we present a strategy for the synthesis of a coumarin fluorophore and a 4-((4-(dimethylamino)phenyl)diazenyl)benzoic acid (DABCYL) ester chromophore incorporated as a FRET pair within a single phosphonate. Such compounds were designed to deliver a BTN3A1 ligand payload to its intracellular receptor. Both final products and some synthetic intermediates were evaluated for their ability to undergo metabolic activation in γδ T cell functional assays, and for their photophysical properties by spectrophotometry. One phosphonate bearing a DABCYL acyloxyester and a novel tyramine-linked coumarin fluorophore exhibited strong, rapid, and potent cellular activity for γδ T cell stimulation and also showed FRET interactions. This strategy demonstrates that bioactivatable phosphonates containing FRET pairs can be utilized to develop probes to monitor cellular uptake of otherwise charged payloads.
- Harmon, Nyema M.,Huang, Xueting,Hsiao, Chia-Hung Christine,Wiemer, Andrew J.,Wiemer, David F.
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- Perceptive variation of carboxylate ligand and probing the influence of substitution pattern on the structure of mono- and di-butylstannoxane complexes
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By reacting 2- and 3-aminobenzoic acids (HL1and HL2, respectively), as well as 2-, 3- and 4-{(E)-2-[4-(dimethylamino)phenyl]diazenyl}benzoic acids (HL3, HL4and HL5, in this order) with a n-butyltin(IV) source [nBuSn(O)OH ornBu2SnO], the drum-type butylstannoxane complexes of general composition [nBu6Sn6O6(Ln)6] [Ln?=?L1(1), L2(2) and L3(3)] and the ladder-type compounds [nBu8Sn4O2(Ln)4] [Ln?=?L3(5), L4(6) and L5(7)] were obtained and fully characterized. By reacting 1 with 2-{(E)-[4-(dimethylamino)benzylidene]amino}benzoic acid (HL6), a co-crystal (4) was achieved which comprises the metal complex aggregate found in 1 and the neutral HL6molecule. The solution properties of the compounds were assessed from1H and13C NMR studies and, for the metal complexes, also from119Sn NMR. The molecular structures of 1, 2, 4–7 were confirmed by single-crystal X-ray diffraction. Compounds 1–3 and the complex moiety of 4 display hexameric Sn6O6clusters with drum-like structures, but 5–7 reveal Sn4O2cores with ladder-type structural motifs. Besides the observed relationship between the ligand N-functional group and obtained (drum- or ladder-type) assemblies, the relative position of the carboxylate group in the ligand itself influences its coplanarity.
- Basu Baul, Tushar S.,Dutta, Dhrubajyoti,Duthie, Andrew,Guedes da Silva, M. Fátima C.
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p. 627 - 637
(2016/11/30)
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- COLORING AGENTS NATURALISED WITH THE 6'-DEOXY-6'-(PIPERAZINYL)LACTOSE MOIETY
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The present application refers to colouring products of formula (I) soluble in water at room temperature. Here a piperazine unity is inserted, bonded directly to the saccharidic unity. This moiety afford to the final glycoconjugated colorants some very advantageous characteristics for dyeing leather, textiles, wood and hairs.
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Page/Page column 37-38
(2014/11/13)
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- Amide isosteres in structure-activity studies of antibacterial minor groove binders
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Antibacterial minor groove binders related to the natural product, distamycin, are development candidates for novel antibiotics. Alkenes have been found to be effective substitutes for the isosteric amide links in some positions and alkyl groups larger th
- Khalaf, Abedawn I.,Anthony, Nahoum,Breen, David,Donoghue, Gavin,MacKay, Simon P.,Scott, Fraser J.,Suckling, Colin J.
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experimental part
p. 5343 - 5355
(2012/01/06)
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- Liquid/liquid separation of polysiloxane-supported catalysts
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Liquid/liquid separation after monophasic reactions is a viable way to use and recover polysiloxane-supported catalysts. The Royal Society of Chemistry 2006.
- Grunlan, Melissa A.,Regan, Katherine R.,Bergbreiter, David E.
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p. 1715 - 1717
(2008/10/09)
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- Dual resonance energy transfer nucleic acid probes
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Dual nucleic acid probes with resonance energy transfer moieties are provided. In particular, fluorescent or luminescent resonance energy transfer moieties are provided on hairpin stem-loop molecular beacon probes that hybridize sufficiently near each other on a subject nucleic acid, e.g. mRNA, to generate an observable interaction. The invention also provides lanthanide chelate luminescent resonance energy transfer moieties on linear and stem-loop probes that hybridize sufficiently near each other on a subject nucleic acid to generate an observable interaction. The invention thereby provides detectable signals for rapid, specific and sensitive hybridization determination in vivo. The probes are used in methods of detection of nucleic acid target hybridization for the identification and quantification of tissue and cell-specific gene expression levels, including response to external stimuli, such as drug candidates, and genetic variations associated with disease, such as cancer.
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- cis-trans Isomerization of the Azobenzenes Included as Guests in Langmuir-Blodgett Films of Amphiphilic β-Cyclodextrin
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Azobenzenes in the host-guest Langmuir-Blodgett films prepared with amphiphilic β-cyclodextrin and azobenzene derivatives showed a photochromic behavior with complete reversibility owing to the free volume of cyclodextrin cavity, whereas the trans-to-cis isomerization was restricted in the case of the pure LB film prepared with long-chain azobenzene derivative alone.Thermal cis-to-trans isomerizations in the LB films were also studied.
- Yabe, Akira,Kawabata, Yasujiro,Niino, Hiroyuki,Tanaka, Motoo,Ouchi, Akihiko,et al.
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