- Alkylation and Aminomethylation of 1,3-Dihydro-2H-Benzimidazole-2-Thione
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Alkylation of 1,3-dihydro-2H-benzimidazole-2-thione (2-mercaptobenzimidazole) with bromoethane and chloroacetic acid derivatives occurrs at the sulfur atom, leading to the corresponding 2-sulfanylbenz-imidazole derivatives. Aminomethylation of 1,3-dihydro-2H-benzimidazole-2-thione with piperidine and 4-methylpiperidine gives reaction products at both nitrogen atoms, while reaction with morpholine gives derivative at only one nitrogen atom, which is in an equilibrium with the starting compound and bis-adduct in DMSO solution.
- Bespalov,Gorchakova,Ivanov,Kuznetsov,Kuznetsova,Pankova,Prokopenko,Avdontceva
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p. 1547 - 1558
(2015/02/19)
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- Synthesis and spatial structure of 1-(cytisin-1-ylmethyl)benzimidazole-2- thione
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New derivatives of cytisine and anabasine alkaloids containing benzothiazole and benzimidazole fragments were discussed. Physicochemical characteristics of the new compounds were determined. The structure of 1-(cytisin-1-yl-methyl)benzimidazole-2-thione w
- Gazaliev,Ibraev,Isabaeva,Ibataev
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p. 1098 - 1102
(2013/08/23)
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- Behaviour of 2,3-dihydro-1H-benzo[d]imidazole-2-thione towards amines under Mannich-type condition
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2,3-Dihydro-1H-benzo[d]imidazole-2-thione (1) was subjected to a Mannich reaction with either dimethylamine, urotropine, morpholine, thiomorpholine, (±) 3,3,5 trimethylhexahydroazepine, piperazine or p-bromoaniline and formalin in different molar ratios to afford the Mannich bases. The reactivity of the Mannich base 5a towards indole was also investigated. In addition the condensation of hydroxymethyl derivative 10 with morpholine, benzimidazole, p-bromoaniline, tryptamine and aminiothiazole was achieved.
- Hamama
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p. 269 - 271
(2007/10/03)
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