cas 6274-27-7, 2,5-DICHLOROPHENYLTHIOGLYCOLIC ACID | Articles data ｜lookchem

Welcome to LookChem.com Sign In|Join Free

Article Database

Home > CAS Article list >
6274-27-7

Articles about 6274-27-7Total 2 be found

Article title
Article abstract
Author
Journal number and time
Download

Synthesis and anti-MRSA activity of novel cephalosporin derivatives
Cephalosporin derivatives containing a unique combination of lipophilic C-7 sidechains and polar C-3 thiopyridinium groups were synthesized and found to exhibit potent anti-MRSA activity in vitro and in vivo. The optimum C-7 sidechains utilized were 2,5-dichlorophenylthioacetamido and 2,6-dichloropyrid-4-ylthioacetamido. The C-3 thiopyridinium rings were substituted at nitrogen with amino acid and pyruvic acid groups that were designed to confer aqueous solubility as required for IV formulation. This paper describes the characteristics of these novel cephalosporins and highlights synthetic methods developed to allow their practical, large-scale syntheses. (C) 2000 Elsevier Science Ltd.
D'Andrea, Stan V.,Bonner, Daniel,Bronson, Joanne J.,Clark, Junius,Denbleyker, Ken,Fung-Tomc, Joan,Hoeft, Shelley E.,Hudyma, Thomas W.,Matiskella, John D.,Miller, Raymond F.,Misco, Peter F.,Pucci, Michael,Sterzycki, Roman,Tsai, Yuan,Ueda, Yasutsuga,Wichtowski, John A.,Singh, Janak,Kissick, Thomas P.,North, Jeffery T.,Pullockaran, Annie,Humora, Michael,Boyhan, Brenda,Vu, Truc,Fritz, Alan,Heikes,Fox, Rita,Godfrey, Jollie D.,Perrone, Robert,Kaplan, Murray,Kronenthal, David,Mueller, Richard H.
p. 5687 - 5698
(2007/10/03)

Synthesis and structure-activity relationship of C-3 benzoyloxymethyl cephalosporins exhibiting anti-MRSA activities
A series of cephalosporins bearing C-3 benzoyloxymethyl groups were prepared and evaluated for their anti-MRSA activity and plasma stability. They exhibit excellent in vitro activity (MIC = 0.06 ~ 2 μg/mL) against MRSA and excellent stability in human plasma.
Kim, Oak K.,Ueda, Yasutsugu,Mansuri, Muzammil M.,Russell, John W.,Bidwell, Valerie W.
p. 1945 - 1950
(2007/10/03)

More Articles about upstream products of 6274-27-7

More Articles about downstream products of 6274-27-7

Chemical Properties

Melting Point: 129°C
Boiling Point: 356.1oC at 760 mmHg
Flash Point:169.2oC
Density: 1.53g/cm3
Solubility:soluble in Alcohol
Storage Temp.:Sealed in dry,Room Temperature
PSA: 62.60000
LogP: 3.17010

Show more

Global suppliers and manufacturers of 6274-27-7total 14 suppliers on LookChem

Company Name
Business Type
Min Order
FOB Price
Main Products
Contact

Dayang Chem (Hangzhou) Co.,Ltd.
Business Type:Lab/Research institutions
Min Order:1 Kilogram
FOB Price:USD $ 3.0-3.0 / Kilogram
Main Products:993
Country:

Zhuozhou Wenxi import and Export Co., Ltd
Business Type:Trading Company
Min Order:1 Kilogram
FOB Price:USD $ 139.0-210.0 / Kilogram
Main Products:1
Country:

Hebei Sankai Chemical Technology Co., Ltd
Business Type:Trading Company
Min Order:1 Metric Ton
FOB Price:USD $ 20.0-30.0 / Metric Ton
Main Products:11
Country:

Zibo Hangyu Biotechnology Development Co., Ltd
Business Type:Lab/Research institutions
Min Order:10 Gram
FOB Price:No Data
Main Products:3496
Country:

GIHI CHEMICALS CO.,LIMITED
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:80
Country:

Henan Allgreen Chemical Co.,Ltd
Business Type:Manufacturers
Min Order:No Data
FOB Price:No Data
Main Products:34
Country:

Antimex Chemical Limied
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:163
Country:

Henan Tianfu Chemical Co., Ltd.
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:67
Country:

Hangzhou Fandachem Co.,Ltd
Business Type:Other
Min Order:No Data
FOB Price:No Data
Main Products:52
Country:

Chemlyte Solutions
Business Type:Other
Min Order:No Data
FOB Price:No Data
Main Products:198
Country:

ZHEJIANG JIUZHOU CHEM CO.,LTD
Business Type:Trading Company
Min Order:No Data
FOB Price:No Data
Main Products:26
Country:

Amadis Chemical Co., Ltd.
Business Type:Lab/Research institutions
Min Order:10 Milligram
FOB Price:No Data
Main Products:1
Country:

Jilin haofei import and export trade Co.,Ltd
Business Type:Trading Company
Min Order:No Data
FOB Price:No Data
Main Products:1
Country:

NovaChemistry
Business Type:Trading Company
Min Order:No Data
FOB Price:No Data
Main Products:1
Country:

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 6274-27-7

About us - Payment - Contact us - Links - Help Center - Disclaimer
SiteMap | Manufacturers | VIP Product | Suppliers | CAS | New CAS | Cas Database | Article Data | Chemical Catalog | Product Name

©2008 LookChem.com,License:ICP NO.:Zhejiang16009103 complaints:service@lookchem.com
[Hangzhou]86-571-87562588,87562561,87562573 Our Legal adviser: Lawyer