- NEW MACROCYCLIC LRRK2 KINASE INHIBITORS
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Compounds of formula (I): wherein R, X1, X2, X3, Z1, Z2, Z3, A and Ra are as defined in the description. Medicaments.
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Page/Page column 158-159
(2021/11/13)
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- NK-1 AND SEROTONIN TRANSPORTER INHIBITORS
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The invention encompasses compounds of Formula I, including pharmaceutically acceptable salts, their pharmaceutical compositions, and their use in treating disorders associated with an excess or imbalance of tachykinins or serotonin or both.
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Page/Page column 82
(2010/11/28)
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- Substituted imidazol-pyridazine derivatives
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The present invention relates to compounds of formula wherein A is an unsubstituted or substituted cyclic group; and R is hydrogen or lower alkyl; or a pharmaceutically acceptable acid addition salt thereof. These compounds are NMDA NR-2B receptor subtype specific blockers and are useful in the treatment of neurodegeneration, depression and pain.
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