- Photochemical protection of amines with Cbz and Fmoc groups
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The photochemical conversion of amines into carbamates was achieved using N-Cbz-, N-Fmoc-, and N-Boc-5,7-dinitroindolines. This reaction allows the protection of amines in neutral medium. Primary and unhindered secondary amines were protected to yield their benzyloxycarbonyl- and 9-fluorenylmethoxycarbonyl derivatives efficiently, whereas bulky amines or anilines gave low yields or no product. On the other hand, the formation of N-Boc compounds, although possible, proceeded only with low yields.
- Helgen, Celine,Bochet, Christian G.
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p. 2483 - 2486
(2007/10/03)
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- Preparation of secondary and tertiary amides under neutral conditions by photochemical acylation of amines
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The smooth and neutral acylation of amines to form amides by photoactivation of N-acyl-5,7-dinitroindolines is described. An improved acylation of nitroindolines allows the convenient preparation of N-acylnitroindolines. This reaction makes possible the recycling of the nitroindoline released during the photoactivation.
- Helgen,Bochet
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p. 1968 - 1970
(2007/10/03)
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- A SIMPLE SYNTHESIS OF 7-SUBSTITUTED 1-ACETYL-2,3-DIHYDROINDOLES
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7-Cyano-, 7-hydroxy-, 7-methoxycarbonyl-, 7-methyl-, 7-nitro-, and 7-phenyl-1-acetyl-2,3-dihydroindoles are prepared in two steps (or one pot) from 1-acetyl-2,3-dihydroindole.
- Somei, Masanori,Kawasaki, Toshiya,Ohta, Toshiharu
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p. 2363 - 2366
(2007/10/02)
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