- Long term storage inducer
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PROBLEM TO BE SOLVED: To provide a long-term memory inducing agent.SOLUTION: A long-term memory inducing agent comprises a compound represented by the formula I, pharmaceutically acceptable salt thereof, or solvate thereof.SELECTED DRAWING: None
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Paragraph 0068-0070
(2021/02/25)
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- AQUEOUS COMPOSITION BASED ON POLYOXYMETHYLENE DIALKYL ETHERS (POM) AND THEIR USE FOR THE PRESERVATION AND/OR EMBALMING OF THE HUMAN OR ANIMAL BODY
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The invention relates to a composition comprising: a) a mixture of polyoxymethylene dialkyl ethers (POM) having a restricted specific molecular distributionb) at least one biocidal agentc) at least one pro-penetrating agentd) at least one dyee) optionally, another additiveand water as diluent. It also relates to a non-therapeutic method of preserving and/or embalming a dead human or animal body using the composition, such as the use of this composition for anatomopathological purposes.
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Paragraph 0058-0059
(2020/11/24)
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- Towards a Sustainable Synthesis of Oxymethylene Dimethyl Ether by Homogeneous Catalysis and Uptake of Molecular Formaldehyde
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Oxymethylene dimethyl ethers (OMEn; CH3(-OCH2-)nO-CH3, n=3–5) are a novel class of sustainable synthetic fuels, which are of increasing interest due to their soot-free combustion. Herein a novel anhyd
- Peter, Andreas,Fehr, Samuel M.,Dybbert, Valentin,Himmel, Daniel,Lindner, Ines,Jacob, Eberhard,Ouda, Mohamed,Schaadt, Achim,White, Robin J.,Scherer, Harald,Krossing, Ingo
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supporting information
p. 9461 - 9464
(2018/07/25)
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- Three Binary Azeotropic Systems for 1-(Methoxymethoxy)-propane, 1-(Ethoxymethoxy)-propane, and Methoxy(methoxymethoxy)methane with Three Alcohols at 101.33 kPa: Experimental Data, Correlation, and Purification
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The isobaric vapor-liquid equilibrium (VLE) data for three binary systems of 1-(methoxymethoxy)-propane and ethanol, 1-(ethoxymethoxy)-propane and 1-butanol, methoxy(methoxymethoxy)methane and 1-propanol at 101.33 kPa were measured using an improved Rose still. Three minimum boiling azeotropes were found for three binary systems containing ethanol, 1-butanol, and 1-propanol for which the azeotropic temperature and composition are 349.35 K and 70.95 mol % (ethanol), 384.02 K and 36.02 mol % (1-butanol), 368.68 K and 69.26 mol % (1-propanol), at 101.33 kPa, respectively. The VLE measurements were correlated by the Van Laar, Wilson, and nonrandom two-liquid models, and the results showed that the measurements had a good correlation by using thethree models for the three binary systems, respectively. The measurements of these three binary systems were thermodynamic as checked by the Herington semiempirical method.
- Song, Yu-He,Hou, Xing-Ming,Song, Juan,Zhang, Yue,Wang, Jie,Wei, Ping-He,Li, Cun-Fu
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p. 138 - 146
(2018/01/18)
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- Preparation method of 2,4,6-trioxaheptane and device for preparation method thereof
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The invention relates to the field of chemical industry, in particular to a preparation method of 2,4,6-trioxaheptane and a device for the preparation method thereof. The preparation method of the 2,4,6-trioxaheptane is characterized in that the 2,4,6-trioxaheptane is prepared by reacting formaldehyde with methanol to generate methylal and the 2,4,6-trioxaheptane and separating. According to the preparation method of the 2,4,6-trioxaheptane, provided by the invention, the 2,4,6-trioxaheptane is prepared by reacting the formaldehyde with the methanol; the preparation method has the advantages of more thorough reaction, high total yield, high product purity, small waste water pollution, safety, environmental friendliness and suitability for industrialized production.
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Paragraph 0052-0055; 0058-0061; 0064-0067; 0070-0073
(2018/11/03)
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- Polyoxymethylene to dimethyl ether synthesis method of polyoxymethylene
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The invention relates to a method for synthesizing polyoxymethylene dimethyl ether by using polyoxymethylene, and the method is mainly used for solving the problems of low reaction efficiency of the traditional catalyst and relatively high cost caused by taking trioxymethylene as a raw material. The problems are better solved according to the technical scheme that methanol, dimethoxymethane and polyoxymethylene are used as raw materials, wherein the mass ratio of methanol to dimethoxymethane to polyoxymethylene is (0-10):(0-10):1, the dosages of methanol and dimethoxymethane cannot be simultaneously equal to zero, the raw materials are in contact with a catalyst to react to generate polyoxymethylene dimethyl ether under the conditions that the reaction temperature is 70-200 DEG C and the reaction pressure is 0.2-6MPa, the dosage of the catalyst accounts for 0.05-10% of the weight of the raw materials, and the adopted catalyst comprises the following components in parts by weight: 30-80 parts of molecular sieve carriers (a) and 20-70 parts of rare earth modified solid super acid (b). The method can be used for industrial production of polyoxymethylene dimethyl ether.
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Paragraph 0015; 0016; 0035; 0036
(2017/03/21)
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- By poly-formaldehyde systems poly formaldehyde method of dimethyl ether
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The invention relates to a method for preparing polyoxymethylene dimethyl ether from paraformaldehyde, and mainly solves the problem in the prior art that the cost is relative high when triformol is adopted as a raw material to synthesize polyoxymethylene dimethyl ether. According to the invention, methanol, dimethoxymethane, and paraformaldehyde are adopted as raw materials, wherein the mass ratio of methanol : dimethoxymethane : paraformaldehyde is (0-10) : (0-10) : 1, wherein the quantities of methanol and dimethoxymethane cannot both be 0; the catalyst is chosen from at least one component of the following tombarthite modified solid superacid: SO4/ZrO2-La2O3, SO4/ZrO2-Ce2O3, Cl/TiO2-La2O3, Cl/TiO2-Ce2O3, Cl/Fe2O3-Ce2O3, SO4/Al2O3-La2O3 or S2O8/ZrO2-La2O3. The technical scheme excellently solves the problem, and can be applied to the industrial production of polyoxymethylene dimethyl ether.
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Paragraph 0015-0016
(2017/02/09)
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- Synthesis of polyoxymethylene dimethyl ethers catalyzed by rare earth compounds
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Polyoxymethylene dimethyl ethers (PODMEn) have been synthesized in moderate yields by the reaction of methylal (PODME1) and paraformaldehyde catalyzed by rare earth compounds. The activities of catalyst in the reaction were investigated and the
- Shi, Gao-Feng,Miao, Jian,Wang, Guo-Ying,Su, Jin-Mei,Liu, Hai-Xiao
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p. 2149 - 2153
(2015/11/28)
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- Shape selectivity extending to ordered supermicroporous aluminosilicates
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In the synthesis of polyoxymethylene dimethyl ethers (PODEn) catalyzed by ordered supermicroporous aluminosilicates, shape selectivity was observed and the high selectivity for target products (PODE3-8) was attributed to the particul
- Fu, Wen Hua,Liang, Xiao Min,Zhang, Haidong,Wang, Yi Meng,He, Ming Yuan
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supporting information
p. 1449 - 1452
(2015/08/03)
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- REACTION SYSTEM AND PROCESS FOR PREPARING POLYMETHOXY DIMETHYL ETHER
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The invention relates to a reaction system and process for continuously preparing polymethoxy dimethyl ether (DMM3-8) by a continuous acetalization reaction between an aqueous formaldehyde solution or paraformaldehyde and methanol in the presen
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Paragraph 0105-0108
(2015/04/15)
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- Reaction system and process for preparing polymethoxy dimethyl ether
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The invention relates to a reaction system and process for continuously preparing polymethoxy dimethyl ether (DMM3-8) by a continuous acetalization reaction between an aqueous formaldehyde solution or paraformaldehyde and methanol in the presence of a functionalized acidic ionic liquid as a catalyst. The reaction system of the invention preferably comprises a formaldehyde-concentrating unit, a vacuum-drying unit, an acetalization reaction unit, a product-separating unit and a catalyst-regenerating unit. The process of the invention uses aqueous formaldehyde solution as an initial raw material, which is concentrated in the formaldehyde-concentrating unit to a concentrated formaldehyde of 50~80 wt.%, and vacuum-dried to paraformaldehyde, or uses paraformaldehyde as raw material directly, then obtains DMM3-8 by an acetalization reaction. The raw materials of the reaction used in the invention are cheap and available easily, and the utilization rate of formaldehyde is high; an efficient separation between the catalyst and product, as well as the reuse of the catalyst and raw materials, are realized by a separation mode of combining extraction and rectification together.
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Paragraph 0073; 0074
(2015/04/15)
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- Rhenium oxide-modified H3PW12O40/TiO2 catalysts for selective oxidation of dimethyl ether to dimethoxy dimethyl ether
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An efficient rhenium oxide-modified H3PW12O40/TiO2 catalyst is found for a new synthesis of dimethoxy dimethyl ether from dimethyl ether oxidation. The effects of Re loading, H3PW12O40 content and different feedstocks on the performance of Re-H3PW12O40/TiO2 were investigated. The results showed that DMM2 selectivity was significantly improved up to 60.0%, with 15.6% of DME conversion over 5% Re-20% H3PW12O40/TiO2. NH3-TPD, NH3-IR, Raman spectra, H2-TPR, XPS and TEM were used to extensively characterize the structure and surface properties of the catalysts. The introduction of H3PW12O40 significantly affected the structure and reducibility of surface rhenium oxide species, in addition to increasing the acidity of the catalyst. The increased number of Lewis acid sites and weak acid sites and the optimal ratio of Re4+/Re7+ of Re-H3PW12O40/TiO2 were favorable for the formation of DMM2 from DME oxidation. The possible reaction pathway of DME oxidation to DMM2 was proposed.
- Zhang, Qingde,Tan, Yisheng,Liu, Guangbo,Zhang, Junfeng,Han, Yizhuo
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p. 4708 - 4715
(2014/12/11)
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- A method for synthesizing polyoxymethylene dimethyl ethers
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The present invention relates to the field of chemical engineering and technology, in particular relates to the sub-field of synthesis of high quality alternative liquid engine fuel from non-petroleum based feedstock, more particularly relates to a method
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Paragraph 0043-0044
(2015/01/16)
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- HYPOXIA INDUCIBLE FACTOR-1 PATHWAY INHIBITORS AND USES AS ANTICANCER AND IMAGING AGENTS
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This disclosure relates to Hypoxia Inducible Factor-1 pathway inhibitors and uses as anticancer and imaging agents. In certain embodiments, the disclosure contemplates compounds and pharmaceutical compositions disclosed herein.
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Page/Page column
(2013/07/05)
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- PERFLOURINATED POLY(OXYMETHYLENE) COMPOUNDS
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Compounds of Formula (I): R1-O-(CF2-O)n-R1, wherein: n is an integer from 2 to 100; and R1 is perfluorinated alkyl or substituted perfluorinated alkyl are described. Also described are methods of preparing the compounds of Formula (I). For example, compounds of Formula (I) can be prepared by providing a poly(oxymethylene) compound and fluohnating the poly(oxymethylene) compound, for instance, via direct aerosol fluorination.
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Page/Page column 20-21
(2010/07/10)
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- METHOD FOR PRODUCING POLYOXYMETHYLENE DIMETHYL ETHERS
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The invention relates to a method for producing a polyoxymethylene dimethyl ether of formula H3CO(CH2O)nCH3, in which n = 2 - 10. According to said method, methylal and trioxane are fed to a reactor and are reac
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Page/Page column 6
(2008/06/13)
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- CARBOCYCLIC COMPOUNDS
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Novel carbocyclic compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.
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- Process for producing ecteinascidin compounds
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The present invention is directed to a synthetic process for the formation of ecteinascidin compounds and related structures, such as the saframycins. In one particularly preferred embodiment, the present invention provides a synthetic route for the formation of ecteinascidin 743 (1), STR1 an exceedingly potent and rare marine-derived antitumor agent which is slated for clinical trials. The process of this invention is enantio- and stereocontrolled, convergent and short. Also disclosed are novel process intermediates, useful not only in the total synthesis of ecteinascidin 743, but also other known ecteinascidin compounds, including derivatives and analogs thereof.
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- 7-deoxy-6-substituted paclitaxels
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The present invention concerns novel paclitaxel derivatives, their use as antitumor agents, and pharmaceutical formulations.
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- Naphthalene derivatives
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The present invention relates to a naphthalene derivative. More particularly, it relates to a naphthalene derivative exhibiting an excellent activity as a drug.
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- 11β-substituted 16α, 17α-methylene-estra-4,9-dien-3-ones
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11β-substituted-16α, 17α-methylene-estra-4,9-dien-3-ones of formula I STR1 wherein R1 is a methyl or ethyl group; R2 is H; a C1-6 -alkyl, -alkoxymethyl, -alkanoyl or -alkoxcarbonyl group ; 2-methoxyethyl; 2-hydroxyethyl; 2-C1-4 -alkanoyloxyethyl; or a tri-C1-4 -alkylsilyl group; R3 is vinyl; a C1-6 -alkyl; or a phenyl radical para-substituted by --OCH3, --SCH3, --N(CH3), --CN, --CHO, CH3 CO--, CH3 CHOH-- or --CH2 OH; R6 is H or a C1-4 -alkyl group; X is O, a hydroxy- or methoxyimino group (=N?OH or --N?OCH3), or a cyclic thioketal with 2 or 3 carbon ring atoms are provided, as well as pharmaceutical compositions containing said compounds, methods of use of said compounds, and processes for their production.
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- Aromatic derivatives of 13-azaprostanoic acid
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Novel substituted phenyl eicosanoid analogs having the formula: STR1 and their pharmaceutically acceptable esters and salts, wherein: R is H or OH;R 1 is H or lower alkyl;X is --CH 2 --CH 2 -- or cis --CH CH--;Y is --CH 2 --, STR2 --O-- or --S--; n is 0 or 1; and A is (1) an eicosanoid nucleus (ring system), (2) a carbocyclic analog of an eicosanoid nucleus or (3) a heterocyclic analog of an eicosanoid nucleus wherein one of the carbons in a carbocyclic analog is replaced by O, S or N.
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- Hydrolysis of Aldal Acetals
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Eleven aldal acetals were synthesized, and the kinetics of their hydrolyses in water and in water-acetonitrile were studied as model systems for the hydrolysis of sucrose. α,α'-Diethoxypropyl ether (an aldal acetal) hydrolyzes in water without hemiacetal buildup.The reaction is not subject to general acid catalysis and the value of kD3O(+)/kH3O(+) = 2.44, both results being characteristic of an A1 mechanism.The energy of activation for the hydrolysis of α,α'-diethoxydipropyl ether was 84.98 kJ mol -1 in water and showed no temperature dependency over the range of 15 - 35 deg C.The structural effects for the hydrolysis of aldal acetals parallel those for acetal hydrolysis.
- Su Min Oon,Kubler, Donald G.
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p. 1166 - 1171
(2007/10/02)
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- Intermediates for the production of quinones
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A novel method for producing hydroquinone and quinone derivatives by a regio- and stereo-specific coupling reaction of hydroquinone derivative having a terminal activated (poly)prenyl side chain with a prenyl derivative. This method can provide in good yield various hydroquinone and quinone derivatives having any prenyl length of the side chain.
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