Synthesis of pyrazoles and isoxazoles as potent αvβ3 receptor antagonists
We describe a series of pyrazole and isoxazole analogs as antagonists of the αvβ3 receptor. Compounds showed low to sub-nanomolar potency against αvβ3, as well as good selectivity against αIIbβ3
Penning, Thomas D.,Khilevich, Albert,Chen, Barbara B.,Russell, Mark A.,Boys, Mark L.,Wang, Yaping,Duffin, Tiffany,Engleman, V. Wayne,Finn, Mary Beth,Freeman, Sandra K.,Hanneke, Melanie L.,Keene, Jeffery L.,Klover, Jon A.,Nickols, G. Allen,Nickols, Maureen A.,Rader, Randall K.,Settle, Steven L.,Shannon, Kristen E.,Steininger, Christina N.,Westlin, Marisa M.,Westlin, William F.
p. 3156 - 3161
(2007/10/03)
Lignans. 18. Total synthesis and confirmation of the structure of megacerotonic acid
Megacerotonic acid 1 has a highly exceptional structure, since it is probably the only γ-butyrolactone lignan in which the lactone ring is substituted by an aryl, and arylidene and a carboxy group. The structure of this lignan was confirmed by a racemic t
Brown,Dhal,Papin
p. 13061 - 13072
(2007/10/02)
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