- Stable and easily available sulfide surrogates allow a stereoselective activation of alcohols
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Isothiouronium salts are easily accessible and stable compounds. Herein, we report their use as versatile deoxasulfenylating agents enabling a stereoselective, thiol-free protocol for synthesis of thioethers from alcohols. The method is simple, scalable and tolerates a broad range of functional groups otherwise incompatible with other methods. Late-stage modification of several pharmaceuticals provides access to multiple analogues of biologically relevant molecules. Performed experiments give insight into the reaction mechanism.
- Brutiu, Bogdan R.,Drescher, Martina,Matya?ovsky, Ján,Maulide, Nuno,Merad, Jérémy,Pinto, Alexandre,Stopka, Tobias
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p. 7770 - 7774
(2021/06/16)
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- Triphenylphosphine-N-bromosuccinimide mediated chemoselective cyclodehydration of diols
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A triphenylphosphine-N-bromosuccinimide mediated chemoselective cyclodehydration of diols is presented for the synthesis of polysubstituted tetrahydrofurans. 1,4-Diols and their derivatives can be rapidly cyclized to furnish tetrahydrofurans in high yields with one equivalent of Ph3P/NBS. Higher amount of Ph3P/NBS leads to the formation of dibromobutanes.
- Zhao, Shuo,Wu, You,Sun, Qi,Cheng, Tie-Ming,Li, Run-Tao
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p. 1154 - 1162
(2015/04/14)
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- Biomolecule interaction using atomic force microscope
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The present patent application describes a cantilever for atomic force microscopy (AFM), which includes a cantilever body having a fixed end and a free end, the free end having a surface region being chemically modified by a dendron in which a plurality of termini of the branched region of the dendron are bound to the surface, and a terminus of the linear region of the dendron is functionalized.
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Page/Page column
(2014/03/26)
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- Primary alkyl bromides from dimethylthiocarbamates
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The conversion of primary alkyl dimethylthiocarbamates into alkyl bromides using the Vilsmeier reagent occurs in high yields in the presence of other non-acid sensitive and non-nucleophilic functional groups. Georg Thieme Verlag Stuttgart · New York.
- Moynihan, Meghan F.,Tucker, Joseph W.,Abelt, Christopher J.
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experimental part
p. 3565 - 3568
(2009/06/18)
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- Method for preparing n-(γ(v)-bromoalkyl)phthalimides
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The invention concerns a procedure for preparation of N-(ω-bromoalkyl)phthalimides which consists of reacting potassium phthalimide with an α,ω-dibromoalkane without cosolvent, at a temperature from 50° C. to 130° C. by using a molar ratio of α,ω-dibromoalkane to potassium phthalimide from 2.5 to 6, then of removing excess α,ω-dibromoalkane, under reduced pressure at a temperature equal to 150° C. at most, of taking up the reaction medium again with a low boiling point alcohol at a temperature near that of the boiling point of said alcohol, of filtering at this temperature, of cooling the filtrate obtained and then of recovering the N-(ω-bromoalkyl)phthalimide.
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- 2,3-oxidosqualene-lanosterol cyclase inhibitors
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The present invention relates to aminocyclohexanol derivatives useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
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- METHYL ACETATE DERIVATIVES AND PESTICIDE COMPOSITIONS CONTAINING THE SAME AS THE ACTIVE INGREDIENT
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The present invention relates to a methyl acetate derivative shown in the following formula (1), and a pesticide composition containing the same as an active ingredient, particularly a disinfectant and/or an insecticide: (wherein n represents an integer from 5 to 12, and Y represents alkyl, haloalkyl, trimethylsilyl or nitryl.)
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- Synthesis of (R,S)-10-methyloctadecanoic acid (tuberculostearic acid) and key chiral 2-methyl branched intermediates
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Tuberculostearic acid (R)-10-methyloctadecanoic acid, is a characteristic component of pathogenic mycobacteria and related organisms.Sensitive detection of this acid infected material allows rapid detection of mycobacterial disease.A novel, convergent synthesis of tuberculostearic acid and key chiral intermediates is described in this communication, to provide a reference compound.Racemic and (R)- and (S)-1-iodo-2-methyldecanes were synthesised from 1-octanal and 1-carboethoxyethylidenetriphenylphosphorane as initial starting materials. 1-Hydroxyoct-7-yne was made from 1,6-hexanediol by two alternative methods and coupled with the above racemic iodide.Hydrogenation and oxidation of the resulting (R,S)-10-methyloctadec-7-yn-1-ol gave racemic tuberculostearic acid. Keywords: Mycobacterium tuberculosis; Tuberculostearic acid; Acetylene coupling; (R,S)-10-methyloctadecanoic acid; Chiral 2-methyl branched fatty acids
- Wallace, Paul A.,Minnikin, David E.,McCrudden, Katharine,Pizzarello, Andrea
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p. 145 - 162
(2007/10/02)
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