- Preparation method of L-phenylephrine hydrochloride
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The invention relates to a preparation method of L-phenylephrine hydrochloride, and specifically discloses a preparation method of L-phenylephrine hydrochloride, which comprises the steps of chlorination reaction, chiral reduction reaction, amination salifying and recrystallization. The preparation method has the advantages of cheap and easily available raw materials, simple operation process, loweconomic cost, high product yield and the like, and the product quality meets the standard requirements of Chinese Pharmacopoeia and European Pharmacopoeia.
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Paragraph 0063-0065
(2020/10/04)
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- IMPROVED SYNTHESIS OF MONO-CHLORINATED ACETOPHENONE
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The present invention relates to the improved synthesis of chlorinated acetophenones (CAP) of formula (I). Particularly, the invention shows a way how to reduce the use of chlorinated solvents and the formation of chlorinated volatile by-products in the synthesis.
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Page/Page column 8; 10; 11; 17; 18; 19; 22
(2019/07/13)
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- Mild and efficient α-chlorination of carbonyl compounds using ammonium chloride and oxone (2KHSO5·KHSO4· K2SO4)
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A simple protocol for the α-monochlorination of ketones and 1,3-dicarbonyl compounds utilizing NH4Cl as a source of chlorine and Oxone as an oxidant in methanol without catalyst is presented. The reaction proceeds at ambient temperature in yields ranging from moderate to excellent.
- Swamy, Peraka,Kumar, MacHarla Arun,Reddy, Marri Mahender,Narender, Nama
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supporting information; experimental part
p. 432 - 434
(2012/06/01)
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