IMPROVED SYNTHESIS OF LYSINE ACETYLSALICYLATE · GLYCINE PARTICLES
The invention relates to a method for the production of acetylsalicylic acid lysinate, optionally lysine acetylsalicylate · glycine, comprising the following steps: a) providing a solution of acetylsalicylic acid in ethanol; b) providing an aqueous solution of lysine; c) combining the solutions of step a) and b) to form a mixture; d) optionally stirring the mixture; e) adding acetone to the mixture; f) incubating the mixture, to allow the formation of a acetylsalicylic acid lysinate product; g) isolating the acetylsalicylic acid lysinate product; wherein acetylsalicylic acid is used in excess compared to lysine and wherein no seed crystals are added to the mixture; and optionally the following further steps: h) providing a recrystallized glycine; wherein the glycine has been recrystallized with the following steps: h1) dissolving glycine in water; h2) adding acetone to the glycine solution; h3) stirring the mixture until a precipitate is obtained; i) combining the recrystallized glycine of step h) with the acetylsalicylic acid lysinate product of step g) to obtain lysine acetylsalicylate · glycine (LASAG) particles.
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Page/Page column 13
(2018/07/26)
METHOD FOR PREPARING A SALT OF ACETYLSALICYLIC ACID AND A BASIC AMINO ACID
A method for preparing a salt of acetylsalicylic acid and a basic amino acid. A solution of acetylsalicylic acid and a solution of said basic amino acid are mixed in a reactor, at a temperature lower than or equal to 30° C. at atmospheric pressure. The mixture is created by simultaneously and progressively introducing the acetylsalicylic acid and the basic amino acid into the reactor in amounts that are always equimolar.
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Paragraph 0079; 0080-0113; 0252
(2017/04/11)
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