cas 629664-81-9, 3-(3,4-Difluorobenzoyl)-1,2,3,6-tetrahydro-1,1-dimethylazepino[4,5-b]indole-5-carboxylic acid 1-methylethyl ester

Articles about 629664-81-9Total 4 be found

Article title
Article abstract
Author
Journal number and time
Download

Discovery of XL335 (WAY-362450), a highly potent, selective, and orally active agonist of the farnesoid X receptor (FXR)
Azepino[4,5-b]indoles have been identified as potent agonists of the farnesoid X receptor (FXR). In vitro and in vivo optimization has led to the discovery of 6m (XL335, WAY-362450) as a potent, selective, and orally bioavailable FXR agonist (EC50 = 4 nM, Eff = 149%). Oral administration of 6m to LDLR-/- mice results in lowering of cholesterol and triglycerides. Chronic administration in an atherosclerosis model results in significant reduction in aortic arch lesions.
Flatt, Brenton,Martin, Richard,Wang, Tie-Lin,Mahaney, Paige,Murphy, Brett,Gu, Xiao-Hui,Foster, Paul,Li, Jiali,Pircher, Parinaz,Petrowski, Mary,Schulman, Ira,Westin, Stefan,Wrobel, Jay,Yan, Grace,Bischoff, Eric,Daige, Chris,Mohan, Raju
supporting information; experimental part
p. 904 - 907
(2009/12/24)

AZEPINOINDOLE DERIVATIVES AS PHARMACEUTICAL AGENTS
The present invention relates to compounds of formula I, which exhibit affinity for the farnesoid X receptor.
-
Page/Page column 125-126

(2008/06/13)

Azepinoindole derivatives as pharmaceutical agents
Compounds, compositions and methods for modulating the activity of receptors are provided. In particular, compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors.
-
(2008/06/13)

AZEPINOINDOLE AND PYRIDOINDOLE DERIVATIVES AS PHARMACEUTICAL AGENTS
The present invention is directed to compounds of formula (I) and formula (II): formula (I) and (II), wherein R1-R8, A and n are as described in the description. These compounds are used in pharmaceutical compositions and methods for modulating the activity of orphan nuclear receptors.
-
Page 177

(2008/06/13)

Chemical Properties

Boiling Point: 617.283oC at 760 mmHg
Flash Point:327.121°C
Density: 1.275
Storage Temp.:room temp
Vapor Pressure: 0mmHg at 25°C
PKA: 16.49±0.60(Predicted)
PSA: 62.40000
LogP: 5.11010

Global suppliers and manufacturers of 629664-81-9total 36 suppliers on LookChem

Company Name
Business Type
Min Order
FOB Price
Main Products
Contact

Dayang Chem (Hangzhou) Co.,Ltd.
Business Type:Lab/Research institutions
Min Order:1 Kilogram
FOB Price:USD $ 3.0-3.0 / Kilogram
Main Products:994
Country:

Zhuozhou Wenxi import and Export Co., Ltd
Business Type:Trading Company
Min Order:1 Kilogram
FOB Price:USD $ 139.0-210.0 / Kilogram
Main Products:1
Country:

Triumph International Development Limilted
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:24
Country:

Taizhou Crene Biotechnology co.ltd
Business Type:Lab/Research institutions
Min Order:1 Gram
FOB Price:No Data
Main Products:16
Country:

Hangzhou J&H Chemical Co., Ltd.
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:46
Country:

Xiamen Jenny Chemical Technology Co., Ltd.
Business Type:Trading Company
Min Order:1 Milligram
FOB Price:No Data
Main Products:33
Country:

SAGECHEM LIMITED
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:33
Country:

Bluecrystal chem-union
Business Type:Trading Company
Min Order:1 Metric Ton
FOB Price:USD $ 1.0-1.0 / Metric Ton
Main Products:7
Country:

Shandong Jiling Chemical Co., Ltd
Business Type:Other
Min Order:No Data
FOB Price:No Data
Main Products:27
Country:

Henan Allgreen Chemical Co.,Ltd
Business Type:Manufacturers
Min Order:No Data
FOB Price:No Data
Main Products:34
Country:

Antimex Chemical Limied
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:163
Country:

Guangdong Juda Chemical Industrial Co.,Limited
Business Type:Trading Company
Min Order:No Data
FOB Price:No Data
Main Products:30
Country:

Hangzhou Fandachem Co.,Ltd
Business Type:Other
Min Order:No Data
FOB Price:No Data
Main Products:52
Country:

Henan Kanbei Chemical Co.,LTD
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:61
Country:

BOC Sciences
Business Type:Trading Company
Min Order:No Data
FOB Price:No Data
Main Products:41
Country:

Shanghai Yuanye Bio-Technology Co., Ltd.
Business Type:Trading Company
Min Order:No Data
FOB Price:No Data
Main Products:31
Country:

Shanghai Terui OP New Material Technology Co., Ltd.
Business Type:Trading Company
Min Order:No Data
FOB Price:No Data
Main Products:58
Country:

Shanghai Chinqesen Biotechnology Co., Ltd.
Business Type:Trading Company
Min Order:No Data
FOB Price:No Data
Main Products:79
Country:

Zibo Hangyu Biotechnology Development Co., Ltd
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:3500
Country:

ZHEJIANG JIUZHOU CHEM CO.,LTD
Business Type:Trading Company
Min Order:No Data
FOB Price:No Data
Main Products:27
Country:

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 629664-81-9

Article Database

629664-81-9

Articles about 629664-81-9Total 4 be found

More Articles about upstream products of 629664-81-9

Chemical Properties

Boiling Point: 617.283oC at 760 mmHg

Flash Point:327.121°C

Density: 1.275

Storage Temp.:room temp

Vapor Pressure: 0mmHg at 25°C

PKA: 16.49±0.60(Predicted)

PSA: 62.40000

LogP: 5.11010

Global suppliers and manufacturers of 629664-81-9total 36 suppliers on LookChem