- Method for preparing phenytoin sodium
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The invention relates to the field of biological medicines, and discloses a method for preparing phenytoin sodium. The method is characterized by comprising the following steps: (1) carrying out an oxidation reaction on benzoin in a first solvent to obtain diphenyl ethanedione, wherein the first solvent is a mixed solution of an alcohol and water, and the alcohol is at least one selected from C1-C3 monohydric alcohols; (2) carrying out a rearrangement reaction on diphenyl ethanedione to obtain phenytoin; and (3) carrying out salt forming reaction on the phenytoin in water, and performing purifying to obtain the phenytoin sodium. According to the method provided by the invention, few solvent systems are introduced, acetic acid is prevented from being used, subsequent treatment is relativelysimple, and the prepared phenytoin sodium is relatively high in yield and purity and is convenient to large-scale production.
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Paragraph 0079; 0083; 0086; 0088; 0091; 0093; 0096-0119
(2020/12/08)
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- Synthetic method of phenytoin sodium
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The invention relates to a synthetic method of phenytoin sodium, belonging to the technical field of biomedicine. The synthetic method of the phenytoin sodium comprises the following steps of oxidation reaction, condensation reaction and salt formation reaction, wherein a amidation reaction process is promoted through adding a phase transfer catalyst 4-dimethylamiopryidine in the condensation reaction; a two-phase system of n-butanol and water is adopted, so that the generation of diphenylacetylene diurea is greatly inhibited, and reaction time is obviously shortened; ethanol serves as a solvent in the salt formation reaction, after a sodium hydroxide ethanol solution reacts with phenytoin, cyclohexane with defective solvent ice is added to promote the phenytoin sodium to precipitate as white crystal, and compared with the salt formation reaction with water as a solvent, the phenytoin sodium is faster in precipitation rate and high in precipitation degree and purity.
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Paragraph 0025; 0034; 0038; 0039; 0042; 0046; 0050
(2019/03/28)
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- AN IMPROVED PROCESS FOR THE PREPARATION OF PHENYTOIN SODIUM
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The present invention relates to an improved process for the preparation of Phenytoin Sodium of formula (I) by reacting Phenytoin with aqueous solution of Sodium hydroxide in presence of aqueous Sodium chloride.
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Page/Page column 3-6
(2008/06/13)
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